1289485-42-2

Basic information

• Product Name: 2-(4-chloro-2-hydroxyphenyl)isoindoline-1,3-dione
• Synonyms: 2-(4-chloro-2-hydroxyphenyl)isoindoline-1,3-dione
• CAS NO: 1289485-42-2
• Molecular Weight: 273.675
• Mol File: 1289485-42-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-(4-chloro-2-hydroxyphenyl)isoindoline-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-chloro-2-hydroxyphenyl)isoindoline-1,3-dione(1289485-42-2)
• EPA Substance Registry System: 2-(4-chloro-2-hydroxyphenyl)isoindoline-1,3-dione(1289485-42-2)

Safety Data

• Hazardous Substances Data: 1289485-42-2(Hazardous Substances Data)

Upstream product

• 7386-21-2 N-(4-chlorophenyl)phthalimide 
• 85-44-9 phthalic anhydride 
• 106-47-8 4-chloro-aniline 
• 28443-50-7 2-amino-5-chlorophenol 

Downstream Products

• 1289485-67-1 N-(2-(benzyloxy)-4-chlorophenyl)methanesulfonamide 
• 1289485-85-3 N-(2-(benzyloxy)-4-chlorophenyl)-1-(3-(4-methoxytetrahydro-2H-pyran-4-yl)phenyl)methane-sulfonamide 
• 1289485-95-5 N-(2-(benzyloxy)-4-chlorophenyl)-N-(3-(4-methoxytetrahydro-2H-pyran-4-yl)benzyl)methanesulfonamide 
• 1289486-04-9 2-(benzyloxy)-4-chloro-N-(3-(4-methoxytetrahydro-2H-pyran-4-yl) benzyl) aniline 
• 1289485-50-2 C₂₁H₁₄ClNO₃ 

Relevant articles and documents

Stereoselective Synthesis of Functionalized Benzooxazepino[5,4- a] isoindolone Derivatives via Cesium Carbonate Catalyzed Formal [5 + 2] Annulation of 2-(2-Hydroxyphenyl)isoindoline-1,3-dione with Allenoates

In this work, we present a strategy for the stereoselective synthesis of functionalized benzooxazepino[5,4-a]isoindolone derivatives via a Cs2CO3-catalyzed domino β-addition and γ-aldol reaction of 2-(2-hydroxyphenyl)isoindoline-1,3-dione derivatives with allenoates, which offers an avenue for a combination of the structural unity between benzooxazepine and isoindolone motifs in synthetically useful yields with high stereoselectivities under mild conditions. Remarkably, it is the first example of highly stereoselective Cs2CO3-catalyzed formal [5 + 2] annulation of 2-(2-hydroxyphenyl)isoindoline-1,3-dione with allenoates.

Ru-Catalyzed Selective C-H Bond Hydroxylation of Cyclic Imides

We report on cyclic imides as weak directing groups for selective monohydroxylation reactions using ruthenium catalysis. Whereas acyclic amides are known to promote the hydroxylation of the C(sp2)-H bond enabling five-membered ring ruthenacycle intermediates, the cyclic imides studied herein enabled the hydroxylation of the C(sp2)-H bond via larger six-membered ruthenacycle intermediates. Furthermore, monohydroxylated products were exclusively obtained (even in the presence of overstoichiometric amounts of reagents), which was rationalized by the difficulty to accommodate coplanar intermediates once the first hydroxyl group was introduced into the substrate. The same reactivity was observed in the presence of palladium catalysts.