129086-11-9

Basic information

• Product Name: Tosylate of Hexaethylene glycol monobenzyl ether
• Synonyms: Tosylate of Hexaethylene glycol monobenzyl ether;Ts-PEG6-Bn;2,5,8,11,14,17-Hexaoxanonadecan-19-ol, 1-phenyl-,4-methylbenzenesulfonate;1-phenyl-2,5,8,11,14,17-hexaoxanonadecan-19-yl 4-methylbenzenesulfonate;1-phenyl-2,5,8,11,14,17-hexaoxanonadecan-19-yl 4-methylbenzenesulfonate(WXC06922)
• CAS NO: 129086-11-9
• Molecular Formula: C₂₆H₃₈O₉S
• Molecular Weight: 526.63952
• Mol File: 129086-11-9.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Tosylate of Hexaethylene glycol monobenzyl ether(CAS DataBase Reference)
• NIST Chemistry Reference: Tosylate of Hexaethylene glycol monobenzyl ether(129086-11-9)
• EPA Substance Registry System: Tosylate of Hexaethylene glycol monobenzyl ether(129086-11-9)

Safety Data

• Hazardous Substances Data: 129086-11-9(Hazardous Substances Data)

Upstream product

• 24342-68-5 1-phenyl-2,5,8,11,14,17-hexaoxanonadecan-19-ol 
• 98-59-9 p-toluenesulfonyl chloride 
• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 
• 2615-15-8 pentaethylene glycol 
• 42749-28-0 toluene-4-sulfonic acid 2-[2-(2-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethyl ester 

Downstream Products

• 129086-15-3 (2-{2-[2-(2-{2-[2-(2,2,3,3,4,4,5,5,6,6,7,7,7-Tridecafluoro-heptyloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxymethyl)-benzene 
• 86770-78-7 2-[2-(2-{2-[2-(2-Benzyloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethylamine 
• 86770-73-2 {2-[2-(2-{2-[2-(2-Azido-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxymethyl}-benzene 
• 129086-19-7 (2-{2-[2-(2-{2-[2-(2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-Pentadecafluoro-octyloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxymethyl)-benzene 

Relevant articles and documents

Multigram Synthesis of Well-Defined Extended Bifunctional Polyethylene Glycol (PEG) Chains

A series of novel, well-defined, unsymmetrical poly(ethylene glycol) chains of the type X(OCH2-CH2)nY (where X = protecting group; Y = nucleofuge or a different protecting group; n = 3, 6, 9, 12, 15, 18, and 24) were prepared in high yields by applying orthogonal protecting groups. The purity of the compounds was fully verified by elemental and high-resolution mass spectrometry analyses.

Lack of effect of the length of oligoglycine- and oligo(ethylene glycol)-derived para-substituents on the affinity of benzenesulfonamides for carbonic anhydrase II in solution

Using 1H NMR spectroscopy, values of T2 have been determined for the methylene protons of the oligoglycine moieties of para-substituted benzenesulfonamides having structures H2NO2SC6H4CO(Gly)(n)OH (n = 1-6) bound at the active site of bovine carbonic anhydrase II (CA, EC 4.2.1.1). These values have been correlated with measurements of dissociation constants of these complexes, in order to infer motion of these ligands when bound to the enzyme. Motion of glycines 1-3 (those closest to the aryl ring) is hindered by their proximity to the protein; motion of glycines 4-6 is relatively unhindered. Despite the restriction to motion inferred for glycines 1-3, the values of K(d) for the six compounds (n = 1-6, 1-6) are indistinguishable within experimental uncertainty (± 20%): K(d) in μM (n) 0.30 (1); 0.26 (2); 0.33 (3); 0.37 (4); 0.37 (5); 0.34 (6). There is, therefore, an unexpected compensation of the loss in conformational entropy on binding by another contributor to the free energy.