129120-96-3Relevant articles and documents
Synthesis and antihypertensive activity of 3-acetoxy-2,3-dihydro-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-1 ,5-benzothiazepin-4(5H)-one (diltiazem) derivatives having substituents at the 8 position
Yanagisawa,Fujimoto,Shimoji,Kanazaki,Mizutari,Nishino,Shiga,Koike
, p. 2055 - 2061 (2007/10/02)
In order to improve the potency and duration of biological actions of diltiazem, a number of 1,5-benzothiazepine derivatives having the substituents at the 8 position were prepared and evaluated for their antihypertensive activity in spontaneously hyperte