129376-64-3

Basic information

• Product Name: [(E)-2-(2-Methyl-1H-indol-3-yl)-ethylimino]-acetic acid (1S,2R,5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester
• CAS NO: 129376-64-3
• Molecular Weight: 444.617
• Mol File: 129376-64-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [(E)-2-(2-Methyl-1H-indol-3-yl)-ethylimino]-acetic acid (1S,2R,5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [(E)-2-(2-Methyl-1H-indol-3-yl)-ethylimino]-acetic acid (1S,2R,5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester(129376-64-3)
• EPA Substance Registry System: [(E)-2-(2-Methyl-1H-indol-3-yl)-ethylimino]-acetic acid (1S,2R,5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester(129376-64-3)

Safety Data

• Hazardous Substances Data: 129376-64-3(Hazardous Substances Data)

Upstream product

• 2731-06-8 2-methyltryptamine 
• 129444-92-4 (1S,2R,5S)-5-Methyl-2-(1-methyl-1-phenylethyl)cyclohexyl glyoxylate 
• 2826-91-7 (E)-2-methyl-3-(2-nitrovinyl)-1H-indole 
• 104296-24-4 2-Methyl-3-(2-nitroethyl)-1H-indole 
• 95-20-5 2-methyl-1H-indole 

Downstream Products

• 129376-66-5 (1S,2R,5S)-5-Methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (2'R,3S)-2-Methyl-1'-(4-toluenesulfonyl)spiro<3H-indole-3,3'-pyrrolidine>-2'-carboxylate 

Relevant articles and documents

48. Diastereoselective Spirocyclization of C-(Alkyloxycarbonyl)formimines of 2-Substituted 1H-Indole-3-ethanamines (= Tryptamines): Basic Studies

C-(Alkoxycarbonyl)formimines of type 15-18 were derived from the 2-substituted tryptamines 2, 9, 10, and 11 and transformed with tosyl chloride into tricyclic 3-spiroindoles of types 19-22 (Scheme 3).The influence of the homochiral alkoxy moieties A-D on the stereochemical outcome of this reaction was studied.Good-to-excellent diastereoselectivities were observed with the (-)-8-(phenylmenth-3-yl)oxy group (B) as homochiral auxiliary.The structures of the tricycles 4, (2'R,3S)-19B, and (2'S,3R)-20C were established by X-ray analysis, the structures of the others by NOE and CD studies, and by chemical correlation.Possibilities to explain the steric course of the spirocyclizations are discussed.