130336-16-2

Basic information

• Product Name: 3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE
• Synonyms: 3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE;1-(3,5-DICHLORO-PHENYL)-2,2,2-TRIFLUORO-ETHANONE;1-(3,5-dichlorophenyl)-2,2,2-trifluoro-1-ethanone;1-(3,5-dichlorophenyl)-2,2,2-trifluoroethan-1-one
• CAS NO: 130336-16-2
• Molecular Formula: C₈H₃Cl₂F₃O
• Molecular Weight: 243.01
• Product Categories: Intermediates
• Mol File: 130336-16-2.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 265℃
• Flash Point: 114℃
• Appearance: /
• Density: 1.506
• Vapor Pressure: 0.00942mmHg at 25°C
• Refractive Index: 1.4980 to 1.5020
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE(130336-16-2)
• EPA Substance Registry System: 3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE(130336-16-2)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 130336-16-2(Hazardous Substances Data)

Usage

Uses

3'',5''-Dichloro-2,2,2-trifluoroacetophenone is a reagent used for enantioselective preparation of benzazephinoindoles bearing trifluoromethylated quaternary stereocenters catalyzed by chiral spirocyclic phosphoric acids

InChI:InChI=1/C8H3Cl2F3O/c9-5-1-4(2-6(10)3-5)7(14)8(11,12)13/h1-3H

Upstream product

• 19752-55-7 1-bromo-3,5-dichlorobenzene 
• 407-25-0 trifluoroacetic anhydride 
• 943436-52-0 1-(3,5-dichlorophenyl)-2,2,2-trifluoro-1-trimethylsilyloxy-1-methoxyethane 
• 104863-67-4 N-methoxy-N-methyltrifluoroacetamide 
• 354-32-5 trifluoracetyl chloride 
• 383-63-1 ethyl trifluoroacetate, 
• 354-34-7 trifluoroacetyl fluoride 
• 10203-08-4 3,5-dichlorobenzaldehyde 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 340-07-8 N-(trifluoroacetyl)piperidine 
• 431-47-0 trifluoroacetic acid-methyl ester 
• 108-70-3 1,3,5-trichlorobenzene 
• 354-31-4 trifluoroacetyl bromide 
• 2923-18-4 sodium 2,2,2-trifluoroacetate 

Downstream Products

• 943436-51-9 1-(4-bromo-3-methylphenyl)-3-(3,5-dichlorophenyl)-3-hydroxy-4,4,4-trifluorobutane-1-one 
• 943436-54-2 (Z)-1-(4-bromophenyl)-3-(3,5-dichlorophenyl)-4,4,4-trifluoro-2-butene-1-one 
• 1095275-39-0 Methyl 4-(3-(3,5-dichlorophenyl)-4,4,4-trifluoro-2-butenoyl) benzoate 
• 943436-76-8 1-(3-bromo-4-methylphenyl)-3-(3,5-dichlorophenyl)-4,4,4-trifluoro-3-hydroxybutane-1-one 
• 864725-22-4 1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene 
• 933451-84-4 2-(3,5-dichlorophenyl)-1,1,1-trifluoro-3-nitropropan-2-ol 
• 1296874-64-0 5-(3,5-dichlorophenyl)-5-(trifluoromethyl)oxazolidin-2-one 
• 1296874-77-5 4-[5-(3,5-dichlorophenyl)-2-oxo-5-(trifluoromethyl)-1,3-oxazolidin-3-yl]-2-(trifluoromethyl)benzonitrile 
• 1296870-13-7 tert-butyl {4-[5-(3,5-dichlorophenyl)-2-oxo-5-(trifluoromethyl)-1,3-oxazolidin-3-yl]-2-(trifluoromethyl)benzyl}carbamate 
• 1296870-00-2 3-[4-(aminomethyl)-3-(trifluoromethyl)phenyl]-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-1,3-oxazolidin-2-one 
• 1296870-02-4 N-{4-[5-(3,5-dichlorophenyl)-2-oxo-5-(trifluoromethyl)-1,3-oxazolidin-3-yl]-2-(trifluoromethyl)benzyl}propanamide 
• 1296879-57-6 α-(aminomethyl)-3,5-dichloro-α-(trifluoromethyl)-benzenemethanol 
• 864730-52-9 4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methylbenzoic acid amide 

Relevant articles and documents

Preparation method of 3, 5-substituted-4-amino trifluoroacetophenone and derivatives thereof

The invention relates to the field of organic pharmaceutical synthesis, in particular to a preparation method of 3, 5-substituted-4-amino trifluoroacetophenone and derivatives thereof, and the preparation method of the 3, 5-substituted-4-amino trifluoroacetophenone comprises the following steps: by taking ortho-disubstituted p-aniline as a raw material, carrying out amino protection, acylation reaction and amino deprotection to obtain 4-amino trifluoroacetophenone. The reaction raw materials are simple and easy to obtain, the yield is relatively high, the reaction conditions are mild, and the method has a relatively good industrial application prospect. Besides, on the basis of the reaction, the 3, 5-substituted-4-amino trifluoroacetophenone is further subjected to amino diazotization to prepare the derivative of the 3, 5-substituted-4-amino trifluoroacetophenone, and the derivative has a relatively great application prospect in industry.

Preparation method of trifluoroacetophenone derivative

The invention relates to the field of organic synthesis, in particular to a preparation method of a trifluoroacetophenone derivative. Substituted aniline is used as a raw material, and preparation of the trifluoroacetophenone derivative is completed through three steps including diazotization reaction, coupling reaction and hydrolysis reaction. The preparation method has the advantages of simple process, high yield and less three wastes generated by the whole reaction, and is suitable for large-scale industrial production.

Synthesis method of 3', 5'-dichloro-2, 2, 2-trifluoroacetophenone

The invention relates to the technical field of chemical pharmacy, in particular to a synthesis method of 3', 5' dichloro-2, 2, 2-trifluoroacetophenone. The method comprises the following steps of: reacting 1, 3, 5-trichlorobenzene or 3, 5-dichloro-1-bromobenzene with magnesium to form a Grignard reagent, carrying out nucleophilic addition reaction on the Grignard reagent and a trifluoroacetyl reagent; and carrying out acid treatment to obtain 3', 5'-dichloro-2, 2, 2-trifluoroacetophenone; the method has the advantages of mild reaction conditions, low raw material cost, favorable economic effect and wide industrial production prospects.