340-07-8

Basic information

• Product Name: 1-TRIFLUOROACETYL PIPERIDINE
• Synonyms: 1-Trifluoroacetyl piperidine 97%;1-TRIFLUOROACETYL PIPERIDINE;N-(Trifluoromethylacetyl)piperidine
• CAS NO: 340-07-8
• Molecular Formula: C₇H₁₀F₃NO
• Molecular Weight: 181.1556096
• EINECS: 200-258-5
• Product Categories: Miscellaneous Reagents;Building Blocks;Heterocyclic Building Blocks;Piperidines;Acids and Derivatives;Heterocycles;Piperidine;API intermediates
• Mol File: 340-07-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 77°C/15mmHg(lit.)
• Flash Point: 77 °C
• Appearance: light yellow oil
• Density: 1.226 g/mL at 25 °C
• Vapor Pressure: 0.0256mmHg at 25°C
• Refractive Index: n20/D 1.4171
• Storage Temp.: Refrigerator
• PKA: -1?+-.0.20(Predicted)
• CAS DataBase Reference: 1-TRIFLUOROACETYL PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-TRIFLUOROACETYL PIPERIDINE(340-07-8)
• EPA Substance Registry System: 1-TRIFLUOROACETYL PIPERIDINE(340-07-8)

Safety Data

• Hazard Codes: T
• Statements: 25-50
• Safety Statements: 45-61
• RIDADR: UN 2810
• WGK Germany: 3
• Hazardous Substances Data: 340-07-8(Hazardous Substances Data)

Usage

Description

1-TRIFLUOROACETYL PIPERIDINE is a light yellow oil with chemical properties that make it a versatile reactant in the synthesis of various compounds.

Uses

1-TRIFLUOROACETYL PIPERIDINE is used as a reactant for the synthesis of different types of compounds, each serving specific purposes in various applications.
Used in Pharmaceutical Industry:
1-TRIFLUOROACETYL PIPERIDINE is used as a reactant for the synthesis of photoreactive probes that differentiate the binding sites of noncompetitive GABA receptor antagonists. This application is crucial for understanding the mechanisms of action of these antagonists and potentially developing new treatments for conditions related to GABA receptors.
Used in Biochemical Research:
1-TRIFLUOROACETYL PIPERIDINE is used as a reactant for the synthesis of photoactive a-mannosides and mannosyl peptides. These compounds are essential in studying the biological roles of mannose and its interactions with other molecules, which can be beneficial for developing new therapeutic strategies.
Used in Antibacterial Drug Development:
1-TRIFLUOROACETYL PIPERIDINE is used as a reactant for the synthesis of photoaffinity labeled fusidic acid analogues. Fusidic acid is an antibiotic used to treat certain bacterial infections, and the development of its analogues can lead to more effective treatments with reduced resistance.
Used in Anticonvulsant Drug Development:
1-TRIFLUOROACETYL PIPERIDINE is used as a reactant for the synthesis of hydroxyamides, which have potential anticonvulsant properties. These compounds can be further studied and developed into new medications for the treatment of epilepsy and other seizure disorders.

InChI:InChI=1/C7H10F3NO/c8-7(9,10)6(12)11-4-2-1-3-5-11/h1-5H2

Upstream product

• 110-89-4 piperidine 
• 183266-61-7 1-(trifluoroacetyl)benzotriazole 
• 628-77-3 1,5-diiodopentane 
• 354-38-1 2,2,2-trifluoroacetamide 

Downstream Products

• 711-38-6 4'-methoxy-2,2,2-trifluoroacetophenone 
• 122982-77-8 1-((E)-3-Cyclohexyl-1-trifluoromethyl-propenyl)-piperidine 
• 122982-76-7 1-((Z)-3-Cyclohexyl-1-trifluoromethyl-propenyl)-piperidine 
• 122982-76-7 1-((E)-3-Cyclohexyl-1-trifluoromethyl-propenyl)-piperidine 
• 30724-22-2 2,2,2-trifluoro-1-(3-methoxyphenyl)ethanone 
• 394-59-2 2,2,2-trifluoro-1-(p-tolyl)ethanone 
• 87736-90-1 4-trifluoroacetylbenzaldehyde diethyl acetal 
• 122982-78-9 1-((Z)-4-Phenyl-1-trifluoromethyl-but-1-enyl)-piperidine 
• 122982-79-0 1-((E)-4-Phenyl-1-trifluoromethyl-but-1-enyl)-piperidine 
• 122982-78-9 1-((E)-4-Phenyl-1-trifluoromethyl-but-1-enyl)-piperidine 
• 87736-76-3 1-<(4-tert-butoxymethyl)phenyl>-2,2,2-trifluoro-1-ethanone 
• 127666-67-5 3-[4-(tert-Butyl-dimethyl-silanyloxymethyl)-3,5-dimethyl-phenyl]-3-trifluoromethyl-diaziridine 
• 87736-75-2 1-<4-<(tert-butyldimethylsilyloxy)methyl>phenyl>-2,2,2-trifluoro-1-ethanone 
• 73899-22-6 2-<4-(1-azi-2,2,2-trifluoroethyl)phenyl>ethyl tosylate 

Relevant articles and documents

(Trifluoroacetyl)benzotriazole: A Convenient Trifluoroacetylating Reagent

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