30724-22-2 Usage
Description
3'-METHOXY-2,2,2-TRIFLUOROACETOPHENONE, with the CAS number 30724-22-2, is an organic compound that is widely utilized in the field of organic synthesis due to its unique chemical structure and properties.
Uses
Used in Organic Synthesis:
3'-METHOXY-2,2,2-TRIFLUOROACETOPHENONE is used as a synthetic intermediate for the production of various organic compounds. Its application is primarily due to its unique structure, which allows for the creation of a diverse range of molecules with potential applications in different industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3'-METHOXY-2,2,2-TRIFLUOROACETOPHENONE is used as a key building block in the synthesis of various pharmaceutical compounds. Its utility stems from its ability to be modified and functionalized to create molecules with specific biological activities, contributing to the development of new drugs and therapies.
Used in Chemical Research:
3'-METHOXY-2,2,2-TRIFLUOROACETOPHENONE is also used as a research tool in chemical laboratories. It serves as a model compound for studying various chemical reactions and mechanisms, helping researchers gain a deeper understanding of organic chemistry and potentially leading to the discovery of new synthetic methods and applications.
Used in Material Science:
In the field of material science, 3'-METHOXY-2,2,2-TRIFLUOROACETOPHENONE can be used as a precursor to develop novel materials with specific properties. Its unique structure allows for the creation of materials with tailored characteristics, such as improved stability, reactivity, or selectivity, which can be beneficial in various applications, including catalysis, sensors, and advanced materials.
Preparation
Obtained by adding successively 1.6 M n-BuLi in hexane, then after 10 min, N,N-diethyltrifluoroacetamide (5 min) to a solution of 1-bromo-3-methoxybenzene in THF at ?78° under argon and stirring the mixture for 2 h (88%).
Check Digit Verification of cas no
The CAS Registry Mumber 30724-22-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,0,7,2 and 4 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 30724-22:
(7*3)+(6*0)+(5*7)+(4*2)+(3*4)+(2*2)+(1*2)=82
82 % 10 = 2
So 30724-22-2 is a valid CAS Registry Number.
InChI:InChI=1/C9H7F3O2/c1-14-7-4-2-3-6(5-7)8(13)9(10,11)12/h2-5H,1H3
30724-22-2Relevant articles and documents
Facile diversification of simple benzo[b]thiophenes via thienobenzyne intermediates
Morita, Takamoto,Yoshida, Suguru,Kondo, Masakazu,Matsushita, Takeshi,Hosoya, Takamitsu
, p. 81 - 84 (2017)
Thienobenzynes, which are thiophene-fused novel benzyne species, are efficiently generated via an iodine-magnesium exchange reaction of ortho-iodoaryl triflate-type precursors using a silylmethyl Grignard reagent as the activator. The method allows for facile preparation of a diverse range of multisubstituted benzothiophenes from readily available simple benzothiophenes.
Oxidation of fluoroalkyl alcohols using sodium hypochlorite pentahydrate [1]
Kirihara, Masayuki,Suzuki, Katsuya,Nakakura, Kana,Saito, Katsuya,Nakamura, Riho,Tujimoto, Kazuki,Sakamoto, Yugo,Kikkawa, You,Shimazu, Hideo,Kimura, Yoshikazu
, (2021/02/05)
Fluoroalkyl alcohols are effectivity oxidized to the corresponding fluoroalkyl carbonyl compounds by reaction with sodium hypochlorite pentahydrate in acetonitrile in the presence of acid and nitroxyl radical catalysts. Although the reaction proceeded slower under a nitroxyl radical catalyst- free condition, the desired carbonyl compounds were obtained in high yields. For the reaction with fluoroalkyl allylic alcohols, the corresponding α,β-epoxyketone hydrates were obtained in high yields.
Selective Acylation of Aryl- A nd Heteroarylmagnesium Reagents with Esters in Continuous Flow
Heinz, Benjamin,Djukanovic, Dimitrije,Ganiek, Maximilian A.,Martin, Benjamin,Schenkel, Berthold,Knochel, Paul
supporting information, p. 493 - 496 (2020/01/31)
A selective acylation of readily accessible organomagnesium reagents with commercially available esters proceeds at convenient temperatures and short residence times in continuous flow. Flow conditions allow us to prevent premature collapse of the hemiacetal intermediates despite noncryogenic conditions, thus furnishing ketones in good yields. Throughout, the coordinating ability of the ester and/or Grignard was crucial for the reaction outcome. This was leveraged by the obtention of several bisaryl ketones using 2-hydroxy ester derivatives as substrates.