130749-97-2Relevant articles and documents
The aza-Cope-Mannich approach to Strychnos alkaloids. Short stereocontrolled total syntheses of (±)-dehydrotubifoline and (±)-akuammicine
Angle, Steven R.,Fevig, John M.,Knight, Steven D.,Marquis Jr., Robert W.,Overman, Larry E.
, p. 3966 - 3976 (2007/10/02)
A direct approach for the total synthesis of Strychnos alkaloids has been developed. The key strategic element is the aza-Cope-Mannich rearrangement (Scheme II) of formaldiminium ions derived from azabicyclo[3.2.1]octanols 5 (Scheme I). This reorganizatio