130933-17-4

Basic information

• Product Name: (2S,3aS,7aS)-1-glycinyl>-2-carboxyperhydroindole
• Synonyms: (2S,3aS,7aS)-1-glycinyl>-2-carboxyperhydroindole
• CAS NO: 130933-17-4
• Molecular Weight: 326.393
• Mol File: 130933-17-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,3aS,7aS)-1-glycinyl>-2-carboxyperhydroindole(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3aS,7aS)-1-glycinyl>-2-carboxyperhydroindole(130933-17-4)
• EPA Substance Registry System: (2S,3aS,7aS)-1-glycinyl>-2-carboxyperhydroindole(130933-17-4)

Safety Data

• Hazardous Substances Data: 130933-17-4(Hazardous Substances Data)

Upstream product

• 94062-52-9 (2S,3aS,7aS)-octahydro-1H-indole-2-carboxylic acid phenylmethyl ester 4-methylbenzenesulfonate 

Relevant articles and documents

Configuration and preferential solid-state conformations of perindoprilat (S-9780). Comparison with the crystal structures of other ACE inhibitors and conclusions related to structure-activity relationships

The conformation of perindoprilat, an antihypertensive drug, is studied in the solid state by X-ray analysis. The resolution of its structure reveals important analogies between its observed conformation and that of several ACE inhibitors of the same family. This comparison points out a constant relative orientation of the functional groups, regardless of the molecular environment. This angular constancy appears to us as not being accidental and is a good argument for the spatial design of the ACE binding site. Although ACE is a carboxydipeptidase, the binding site may not contain two but one unique hydrophobic pocket receiving the C-terminal end of the inhibitors.