130973-10-3 Usage
Description
(2E)-3-(3,4-dimethoxyphenyl)-2-propenamide, also known as ferulic acid amide, is a chemical compound with the molecular formula C11H13NO3. It is derived from ferulic acid, an organic compound commonly found in plant cell walls. This trans-isomer has two substituents on the double bond positioned on opposite sides. Studies have shown that (2E)-3-(3,4-dimethoxyphenyl)-2-propenamide possesses potential pharmacological properties, such as anti-inflammatory and antioxidant effects. Additionally, it is being investigated for its possible role in cancer prevention and treatment, making it a promising candidate for further research and development in medicinal chemistry.
Uses
Used in Pharmaceutical Industry:
(2E)-3-(3,4-dimethoxyphenyl)-2-propenamide is used as a pharmaceutical agent for its potential anti-inflammatory and antioxidant effects. Its ability to modulate inflammation and oxidative stress pathways makes it a candidate for the treatment of various inflammatory and oxidative stress-related conditions.
Used in Cancer Prevention and Treatment:
(2E)-3-(3,4-dimethoxyphenyl)-2-propenamide is used as a chemopreventive and therapeutic agent in cancer research. Its potential role in inhibiting cancer cell growth and proliferation, as well as its ability to modulate signaling pathways involved in cancer development, makes it a promising compound for further investigation in oncology.
Used in Drug Development:
(2E)-3-(3,4-dimethoxyphenyl)-2-propenamide is used as a lead compound in drug development for its potential pharmacological properties. Its unique structure and bioactivity make it a valuable starting point for the design and synthesis of new drugs targeting various diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 130973-10-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,0,9,7 and 3 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 130973-10:
(8*1)+(7*3)+(6*0)+(5*9)+(4*7)+(3*3)+(2*1)+(1*0)=113
113 % 10 = 3
So 130973-10-3 is a valid CAS Registry Number.
130973-10-3Relevant articles and documents
Copper(II)-Catalyzed Reactions of α-Keto Thioesters with Azides via C-C and C-S Bond Cleavages: Synthesis of N-Acylureas and Amides
Maity, Rajib,Naskar, Sandip,Das, Indrajit
, p. 2114 - 2124 (2018/02/23)
Cu(II)-catalyzed reaction of α-keto thioesters with trimethylsilyl azide (TMSN3) proceeds with the transformation of the thioester group into urea through C-C and C-S bond cleavages, constituting a practical and straightforward synthesis of N-acylureas. When diphenyl phosphoryl azide (DPPA) is used instead as the azide source in an aqueous environment, primary amides are formed via substitution of the thioester group. The reactions are proposed to proceed through Curtius rearrangement of the initially formed α-keto acyl azide to generate an acyl isocyanate intermediate, which reacts further with an additional amount of azide or water and rearranges to afford the corresponding products. To demonstrate the potentiality of the method, one-step syntheses of pivaloylurea and isovaleroylurea, displaying anticonvulsant activities, have been carried out.
Total synthesis of siphonazole and its O-methyl derivative, structurally unusual bis-oxazole natural products
Linder, Joerg,Blake, Alexander J.,Moody, Christopher J.
supporting information; experimental part, p. 3908 - 3916 (2009/06/28)
The details of the first syntheses of the unusual bis-oxazole natural products siphonazole and its O-methyl derivative are reported. The cinnamyl substituted oxazole was constructed using diazocarbonyl chemistry, whereby the cinnamamide was reacted with the rhodium carbene derived from methyl 2-diazo-3-oxobutanoate to give a β-ketoamide that was cyclodehydrated to the corresponding oxazole-4-ester. Reduction to the corresponding aldehyde was followed by coupling with a zinc reagent derived from methyl 2-iodomethyl-5-methyloxazole-4-carboxylate, also prepared using rhodium carbene chemistry, to give, after oxidation of the resulting secondary alcohol, the desired bis-oxazole ketone. The syntheses were completed by hydrolysis of the ester and coupling of the 2,4-pentadienylamine side chain. The 2008 Royal Society of Chemistry.
