131002-03-4Relevant articles and documents
NEUROPROTECTIVE PDI MODULATING SMALL MOLECULES AND METHODS OF USE THEREOF
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Paragraph 0181; 0186, (2020/06/19)
The present disclosure provides, inter alia, compounds and compositions having the formula (I) as defined herein. Methods of using and making such compounds and compositions are also provided. The present disclosure further provides screening methods, including detectable probes as well as diagnostic methods and methods for monitoring the progress of a disease, such as a neurodegenerative disease.
Nickel-catalyzed regioselective C-H halogenation of electron-deficient arenes
Li, Ze-Lin,Wu, Peng-Yu,Cai, Chun
supporting information, p. 3462 - 3468 (2019/02/25)
A straightforward Ni(ii)-catalyzed general strategy was developed for the ortho-halogenation of electron-deficient arenes with easily available halogenating reagents N-halosuccinimides (NXS; X = Br, Cl and I). The transformation was highly regioselective and a wide substrate scope and functional group tolerance were observed. This discovery could be of great significance for the selective halogenation of amides, benzoic esters and other substances with guiding groups. Mechanistic investigations were also described.
TBAI-catalyzed oxidative synthesis of benzamides from acetophenones and carbinols
Sharif, Muhammad,Chen, Jianbin,Langer, Peter,Beller, Matthias,Wu, Xiao-Feng
supporting information, p. 6359 - 6362 (2014/08/18)
An interesting and convenient procedure for the oxidative transformation of acetophenones and carbinols to primary benzamides has been developed. By using tetra-n-butylammonium iodide (TBAI) as the catalyst and tert-butyl hydroperoxide (TBHP) as the oxidant, the desired benzamides were isolated in moderate to good yields in aqueous solution. Notably, not only acetophenones but also propiophenones can be applied as substrates as well. Hence, we believe that this new procedure is not just a catalytic version of the iodine-based method. the Partner Organisations 2014.