1310708-94-1Relevant articles and documents
Direct Hiyama Cross-Coupling of (Hetero)arylsilanes with C(sp2)-H Bonds Enabled by Cobalt Catalysis
Lu, Ming-Zhu,Ding, Xin,Shao, Changdong,Hu, Zhengsong,Luo, Haiqing,Zhi, Sanjun,Hu, Huayou,Kan, Yuhe,Loh, Teck-Peng
supporting information, p. 2663 - 2668 (2020/03/30)
We report a chelation-assisted C-H arylation of various indoles with sterically and electronically diverse (hetero)arylsilanes enabled by cost-effective Cp*-free cobalt catalysis. Key to the success of this strategy is the judicious choice of copper(II) fluoride as a bifunctional sliane activator and catalyst reoxidant. This methodology features a broad substrate scope and good functional group compatibility. The synthetic versatility of this protocol has been highlighted by the gram-scale synthesis and late-stage diversification of biologically active molecules.
Suzuki-Miyaura coupling of unstrained ketones via chelation-assisted C-C bond cleavage
Jiang, Cheng,Zheng, Zhao-Jing,Yu, Tian-Yang,Wei, Hao
, p. 7174 - 7177 (2018/10/24)
Herein, we report that unstrained ketones can be efficiently employed as electrophiles in Suzuki-Miyaura reactions via catalytic activation of unstrained C-C bonds assist by an N-containing directing group. A wide range of aromatic ketones directly coupled with boronic ester with excellent functional group tolerance. This strategy provides an alternative and versatile approach to constructing biaryls from unstrained ketones.
Rhodium-catalyzed C-H functionalization with N-acylsaccharins
Wu, Hongxiang,Liu, Tingting,Cui, Ming,Li, Yue,Jian, Junsheng,Wang, Hui,Zeng, Zhuo
supporting information, p. 536 - 540 (2017/01/25)
A rhodium-catalyzed C-H functionalization with activated amides by decarbonylation has been developed. Notably, this is the first C-H arylation employing N-acylsaccharins as coupling partners to give biaryls in good to excellent yields. The highlight of the work is the high tolerance of functional groups such as formyl, ester, and vinyl and the use of a removable directing group.