53883-61-7

Basic information

• Product Name: P-fluorophenyltriMethoxysilane
• Synonyms: P-fluorophenyltriMethoxysilane;(4-Fluorophenyl)triMethoxysilane
• CAS NO: 53883-61-7
• Molecular Formula: C₉H₁₃FO₃Si
• Molecular Weight: 216.2816232
• Mol File: 53883-61-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: P-fluorophenyltriMethoxysilane(CAS DataBase Reference)
• NIST Chemistry Reference: P-fluorophenyltriMethoxysilane(53883-61-7)
• EPA Substance Registry System: P-fluorophenyltriMethoxysilane(53883-61-7)

Safety Data

• Hazardous Substances Data: 53883-61-7(Hazardous Substances Data)

Usage

General Description

P-fluorophenyltriMethoxysilane is a chemical compound with the formula C9H11FO3Si. It is a white solid that is insoluble in water but soluble in organic solvents such as ethanol and chloroform. P-fluorophenyltriMethoxysilane is commonly used as a coupling agent in the synthesis of various organic compounds and as a surface modifier in the production of materials such as polymers and glass. It is also used as a building block in the development of pharmaceuticals and agrochemicals. However, it is important to handle this chemical with caution, as it is hazardous if inhaled, swallowed, or in contact with the skin. Proper protective measures should be taken when using and handling P-fluorophenyltriMethoxysilane.

Upstream product

• 681-84-5 tetramethylorthosilicate 
• 460-00-4 1-Bromo-4-fluorobenzene 

Downstream Products

• 114260-45-6 1-(4-fluoro-phenyl)-2,8,9-trioxa-5-aza-1-sila-bicyclo[3.3.3]undecane 
• 53883-56-0 p-fluorophenylsilatranone 
• 324-74-3 4-fluoro-biphenyl 
• 2972-90-9 4,α, β,β-tetrafluoroethenylbenzene 
• 1140233-93-7 N-[4-(fluoro)phenyl]-S-methyl-S-phenylsulfoximine 
• 1310708-94-1 2-(4-fluorophenyl)-1-(pyrimidin-2-yl)-1H-indole 
• 366-63-2 4-fluoro-N-phenylbenzamide 

Relevant articles and documents

Direct Hiyama Cross-Coupling of (Hetero)arylsilanes with C(sp2)-H Bonds Enabled by Cobalt Catalysis

We report a chelation-assisted C-H arylation of various indoles with sterically and electronically diverse (hetero)arylsilanes enabled by cost-effective Cp*-free cobalt catalysis. Key to the success of this strategy is the judicious choice of copper(II) fluoride as a bifunctional sliane activator and catalyst reoxidant. This methodology features a broad substrate scope and good functional group compatibility. The synthetic versatility of this protocol has been highlighted by the gram-scale synthesis and late-stage diversification of biologically active molecules.

Carbon-Silicon Bond Formation in the Synthesis of Benzylic Silanes

Sterically encumbered organosilanes can be difficult to synthesize with conventional, strongly basic reagents; the harsh reaction conditions are often low yielding and not suitable for many functional groups. As an alternative to the typical anionic strat