131320-41-7

Basic information

• Product Name: (R)-(+)-Tetraconazole
• Synonyms: (R)-(+)-Tetraconazole;1-[(R)-2-(2,4-Dichlorophenyl)-3-(1,1,2,2-tetrafluoroethoxy)propyl]-1H-1,2,4-triazole
• CAS NO: 131320-41-7
• Molecular Formula: C13H11Cl2F4N3O
• Molecular Weight: 0
• Mol File: 131320-41-7.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (R)-(+)-Tetraconazole(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-Tetraconazole(131320-41-7)
• EPA Substance Registry System: (R)-(+)-Tetraconazole(131320-41-7)

Safety Data

• Hazardous Substances Data: 131320-41-7(Hazardous Substances Data)

Usage

Description

(R)-(+)-Tetraconazole is a 1-[2-(2,4-dichlorophenyl)-3-(1,1,2,2-tetrafluoroethoxy)propyl]1,2,4-triazole that is the (R)-enantiomer of tetraconazole. It is a chiral molecule with specific biological activity and properties due to its unique stereochemistry.

Uses

Used in Pharmaceutical Industry:
(R)-(+)-Tetraconazole is used as an antifungal agent for the treatment of various fungal infections. Its chiral structure allows for targeted action against fungal pathogens while potentially reducing side effects and toxicity compared to its racemic counterpart.
Used in Crop Protection Industry:
(R)-(+)-Tetraconazole is used as a fungicide in agriculture to protect crops from fungal diseases. Its selective toxicity towards fungi helps maintain crop health and yield while minimizing harm to the environment and non-target organisms.
Used in Research and Development:
(R)-(+)-Tetraconazole is utilized in scientific research for studying the effects of stereochemistry on biological activity and drug efficacy. Its unique properties make it a valuable tool for understanding the mechanisms of enantioselective drug action and developing new chiral drugs with improved safety and efficacy profiles.

Upstream product

• 116-14-3 polytetrafluoroethylene 
• 131216-56-3 (S)-2-(2,4-Dichloro-phenyl)-3-[1,2,4]triazol-1-yl-propan-1-ol 
• 131216-55-2 (R)-2-(2,4-Dichloro-phenyl)-3-[1,2,4]triazol-1-yl-propan-1-ol 
• 112281-77-3 (RS)-2-(2,4-dichlorophenyl)-3-(1H-1,2,4-triazol-1-yl)propyl 1,1,2,2-tetrafluoroethyl ether 
• 131216-60-9 Acetic acid (R)-2-(2,4-dichloro-phenyl)-3-hydroxy-propyl ester 

Downstream Products

• 131320-41-7 (+)-tetraconazole 
• 131320-41-7 (-)-tetraconazole 

Relevant articles and documents

Enantioselective determination of triazole fungice tetraconazole by chiral high-performance liquid chromatography and its application to pharmacokinetic study in cucumber, muskmelon, and soils

A simple chiral high-performance liquid chromatography method with diode array detector was developed and validated for stereoselective determination of tetraconazole enantiomers in cucumber, muskmelon, and soils. Good separation was achieved at 20°C using cellulose tris-(4-methylbenzoate) as chiral stationary phase, a mixture of n-hexane and ethanol (90:10) as mobile phase at a flow rate of 0.8 ml/min. The assay method was linear over a range of concentrations (0.5-50 μg/ml) and the mean recoveries in all samples were more than 85% for the two enantiomers. The limits of detection for both enantiomers in plant and soil samples were 0.06 and 0.12 μg/g, respectively. Then, the proposed method was successfully applied to the study of enantioselective degradation of rac-tetraconazole in cucumber, muskmelon, and soils. The results showed that the degradation of two enantiomers of tetraconazole followed first-order kinetics and significantly stereoselective behavior was observed in cucumber, muskmelon, and Beijing soil. The preferential absorption and degradation of (-)-S-tetraconzole resulted in an enrichment of the (+)-R-tetraconazole residue in plant samples, whereas the (+)-R-tetraconazole showed a faster degradation in Beijing soil and the stereoselectivity might be caused by microorganisms. No stereoselective degradation was observed in Heilongjiang soil. Copyright

PROCESS FOR THE PREPARATION OF TETRACONAZOLE

The present invention relates to a new process for the preparation of Tetraconazole or one of its optically active isomers by means of the fluorination of 2- (2,4- dichlorophenyl) -3- (1H-1, 2, 4-triazol-1-yl) propan-1-ol.

Pyrazolyl benzyl ether derivatives containing a fluoromethoxyimino group and use thereof as pesticides

The invention relates to novel pyrazolyl benzyl ethers, to a plurality of processes for their preparation and to their use for controlling harmful organisms.