1313222-84-2

Basic information

• Product Name: C₂₇H₂₈N₆O
• CAS NO: 1313222-84-2
• Molecular Weight: 452.559
• Mol File: 1313222-84-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₇H₂₈N₆O(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₇H₂₈N₆O(1313222-84-2)
• EPA Substance Registry System: C₂₇H₂₈N₆O(1313222-84-2)

Safety Data

• Hazardous Substances Data: 1313222-84-2(Hazardous Substances Data)

Upstream product

• 107558-48-5 5-(pyridin-4-yl)methyl-2H-phthalazin-1-one 
• 106-49-0 p-toluidine 
• 67592-40-9 3-hydroxy-2-(pyridin-4-yl)-1H-inden-1-one 
• 1236306-14-1 1-(piperazin-1-yl)-4-(pyridin-4-ylmethyl)-phthalazine 
• 16634-82-5 N-(p-tolyl)-2-chloroacetamide 
• 85-44-9 phthalic anhydride 
• 87-41-2 2-benzofuran-1(3H)-one 

Relevant articles and documents

Synthesis and cytotoxic evaluation of some new phthalazinylpiperazine derivatives

A new series of 1,4-disubstituted phthalazinylpiperazine derivatives 7a-f, 12a-f and 20a-f were designed and synthesized in order to develop potent and selective antitumor agents. The target compounds were screened for their cytotoxic activities against A549, HT-29 and MDA-MB-231 cancer cell lines in vitro. Among them, compounds 7a-f exhibited excellent selectivity for MDA-MB-231 with IC50 values ranging from 0.013 μM to 0.079 μM. The most promising compound, 7e (IC50 = 2.19 μM, 2.19 μM, 0.013 μM), was 9.3, 10, and 4.9 × 103 times more active than vatalanib (IC50 = 20.27 μM, 21.96 μM, 63.90 μM), respectively. A new series of 1,4-disubstituted phthalazinylpiperazine derivatives 7a-f, 12a-f and 20a-f were designed and synthesized, and their cytotoxic activities against A549, HT-29 and MDA-MB-231 cancer cell lines in vitro were compared to that of vatalanib.