67592-40-9

Basic information

• Product Name: 3-HYDROXY-2-PYRIDIN-4-YL-INDEN-1-ONE
• Synonyms: 3-HYDROXY-2-PYRIDIN-4-YL-INDEN-1-ONE;3-Hydroxy-2-(pyridin-4-yl)-1H-inden-1-one;3-Hydroxy-2-(4-pyridinyl)-1H-inden-1-one;3-HYDROXY-2-(PYRIDINE-4-YL)INDEN-1-ONE;3-Hydroxy-2-(pyridin-4-yl)
• CAS NO: 67592-40-9
• Molecular Formula: C₁₄H₉NO₂
• Molecular Weight: 223.22676
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 67592-40-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 442.527°C at 760 mmHg
• Flash Point: 221.433°C
• Appearance: /
• Density: 1.407g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.714
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: DMSO
• CAS DataBase Reference: 3-HYDROXY-2-PYRIDIN-4-YL-INDEN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-HYDROXY-2-PYRIDIN-4-YL-INDEN-1-ONE(67592-40-9)
• EPA Substance Registry System: 3-HYDROXY-2-PYRIDIN-4-YL-INDEN-1-ONE(67592-40-9)

Safety Data

• Hazardous Substances Data: 67592-40-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H9NO2/c16-13-10-3-1-2-4-11(10)14(17)12(13)9-5-7-15-8-6-9/h1-8,16H

Upstream product

• 606-23-5 1H-indene-1,3(2H)-dione 
• 15854-87-2 4-iodopyridine 
• 85-44-9 phthalic anhydride 
• 108-89-4 picoline 
• 872-85-5 pyridine-4-carbaldehyde 
• 87-41-2 2-benzofuran-1(3H)-one 

Downstream Products

• 1242606-57-0 C₂₆H₂₅FN₆O 
• 1242606-77-4 C₂₆H₂₄Cl₂N₆O 
• 1242606-79-6 C₂₈H₃₀N₆O 
• 1242606-81-0 C₂₆H₂₅ClN₆O 
• 1242606-83-2 C₂₈H₃₀N₆O 
• 1242606-85-4 C₂₇H₂₇FN₆O 
• 1313222-83-1 C₂₈H₂₄F₆N₆O 
• 1313222-85-3 C₂₆H₂₅FN₆O 
• 1313222-86-4 C₂₇H₂₅F₃N₆O₂ 
• 1313222-87-5 C₂₆H₂₅ClN₆O 
• 1313222-88-6 C₂₇H₂₅F₃N₆O 
• 1313222-84-2 C₂₇H₂₈N₆O 
• 212141-54-3 vatalanib 

Relevant articles and documents

Palladium-Catalyzed Direct α-Arylation of Indane-1,3-dione to 2-Substituted Indene-1,3-diones

A straightforward and feasible palladium-catalyzed direct α-arylation of indane-1,3-dione to 2-substituted aryl/heteroaryl indene-1,3-diones has been disclosed for the first time. Optimization of reaction conditions identified tBu-XPhos as a preferred ligand for the bis(acetonitrile)dichloropalladium(II) catalyst. A broad spectrum of aryl iodides and aryl triflates containing electron-donating, electron-withdrawing, and sterically hindered substituents gave an excellent yield for the quick access α-arylated 1,3-diones library.

Synthesis and antitumor activities of novel 1,4-substituted phthalazine derivatives

A series of 1,4-substituted phthalazine derivatives were designed and synthesized. All the prepared compounds were screened for their cytotoxic activities against A549, HT-29 and MDA-MB-231 cell lines in vitro. Among them, compounds 7a-7h showed excellent selectivity for MDA-MB-231 cell line with IC50 values from 1nmol/L to 0.92μmol/L. A preliminary SAR study of these derivatives was performed.

DIARYLAMINE-CONTAINING COMPOUNDS AND COMPOSITIONS, AND THEIR USE AS MODULATORS OF STEROID HORMONE NUCLEAR RECEPTORS

Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of steroid hormone nuclear receptors, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent diseases or conditions associated with the activity of steroid hormone nuclear receptors.