13136-53-3Relevant articles and documents
A new method for the resolution of amines and its application to 3-amino-1,5-benzodiazepines
Curotto,Donati,Finizia,Ursini
, p. 849 - 852 (1995)
A new method for the resolution of racemic amines and its application to 3-amino-1,5-benzodiazepines is reported. The method is based upon the reaction of the amines with a chiral auxiliary, namely the tosyl derivative of (S)-(+)-methyl mandelate, followe
Application of piperazine structure containing compound to preparation of LSD1 (Lysine Specific Demethylase 1) inhibitor
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Paragraph 0020, (2017/09/29)
The invention discloses application of a piperazine structure containing compound to the preparation of a histone lysine specific demethylase (LSD1) inhibitor. The structural general formula of the compound is as shown in the following descriptions (wherein, A is hydrogen, carbonyl or thiocarbonyl) or a configurational isomer and a pharmaceutical salt thereof, or is as shown in the following descriptions or a pharmaceutical salt thereof. The compound has an obvious inhibition effect on the LSD1, can be prepared into the LSD1 inhibitor, and is used for preventing and treating a disease related to the activity of the histone LSD1.