131423-80-8

Basic information

• Product Name: 2-benzamido-5-chlorothiazolo<5,4-b>pyridine
• Synonyms: 2-benzamido-5-chlorothiazolo<5,4-b>pyridine
• CAS NO: 131423-80-8
• Molecular Weight: 289.745
• Mol File: 131423-80-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-benzamido-5-chlorothiazolo<5,4-b>pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-benzamido-5-chlorothiazolo<5,4-b>pyridine(131423-80-8)
• EPA Substance Registry System: 2-benzamido-5-chlorothiazolo<5,4-b>pyridine(131423-80-8)

Safety Data

• Hazardous Substances Data: 131423-80-8(Hazardous Substances Data)

Upstream product

• 31784-71-1 5-chlorothiazolo[5,4-b]pyridin-2-amine 
• 98-88-4 benzoyl chloride 
• 96938-78-2 N-benzoyl-N'-(2,6-dichloro-3-pyridyl)thiourea 
• 532-55-8 Benzoyl isothiocyanate 
• 1050501-88-6 2-bromo-6-chloro-pyridin-3-amine 

Downstream Products

• 31784-71-1 5-chlorothiazolo[5,4-b]pyridin-2-amine 
• 131423-90-0 1-(5'-chloro-2'-thiazolo<5,4-b>pyridyl)-5-phenyltetrazole 
• 131423-99-9 2-phenyl-6-chloro<1,2,4>triazolo<3',2':2,3>thiazolo<5,4-b>pyridine 

Relevant articles and documents

NOVEL COMPOUNDS FOR DIAGNOSIS

The present invention relates to novel compounds that can be employed in the diagnosis, monitoring of disease progression or monitoring of drug activity of a group of disorders and abnormalities associated with alpha-synuclein (α-synuclein, A-synuclein, aSynuclein, a- synuclein, A-syn, α-syn, aSyn, SNCA, Non-amyloid beta component of Alzheimer's disease (AD) amyloid plaques, Non-A4 component of amyloid precursor, NACP) aggregates including, but not limited to, Lewy bodies and/or Lewy neurites, such as Parkinson's disease (PD). The instant compounds are particularly useful in the diagnosis of the preclinical state of such a disorder, monitoring residual disorder, or predicting the responsiveness of a patient who is suffering from such a disorder to the treatment with a certain medicament.

Formation and Pyrolysis of 1-(2'-Thiazolopyridyl)-5-aryltetrazoles

1-(2'-Thiazolopyridyl)-5-aryltetrazoles (4) have been obtained by the reaction of 2-aroylaminothiazolopyridines (2) with phosphorus pentachloride and azidolysis of the resulting imidoyl chlorides.The products of pyrolysis of 1-(2'-thiazolopyridyl)-5-aryltetrazoles in decalin have been characterised as 2-aryl-1,2,4-triazolothiazolopyridines (6).