131840-54-5

Basic information

• Product Name: N,2'-DIMETHYLFORMANILIDE
• Synonyms: N,2'-DIMETHYLFORMANILIDE;N-METHYL-N-(O-TOLYL)FORMAMIDE;N,2'-Dimethylformanilide
• CAS NO: 131840-54-5
• Molecular Formula: C₉H₁₁NO
• Molecular Weight: 149.18974
• Mol File: 131840-54-5.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 206 °C
• Appearance: /
• Refractive Index: 1.5370-1.5410
• CAS DataBase Reference: N,2'-DIMETHYLFORMANILIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N,2'-DIMETHYLFORMANILIDE(131840-54-5)
• EPA Substance Registry System: N,2'-DIMETHYLFORMANILIDE(131840-54-5)

Safety Data

• Hazardous Substances Data: 131840-54-5(Hazardous Substances Data)

Usage

General Description

N,2'-dimethylformanilide, also known as N, N-dimethyl-2-methoxybenzamide, is a chemical compound with the molecular formula C10H13NO2. It is a colorless to pale yellow liquid that is commonly used as an intermediate in the production of pharmaceuticals, dyes, and other organic compounds. N,2'-dimethylformanilide is known for its strong solvating ability, making it useful as a solvent in various chemical reactions and processes. It is also considered to be relatively stable and safe to handle, with low acute toxicity. However, prolonged or high-level exposure to this compound can cause irritation to the skin, eyes, and respiratory system. Overall, N,2'-dimethylformanilide is an important chemical in the field of organic synthesis and industrial applications.

Upstream product

• 64-18-6 formic acid 
• 611-21-2 N,2-dimethylaniline 
• 124-38-9 carbon dioxide 
• 94-69-9 2'-methylformanilide 
• 74-88-4 methyl iodide 
• 109-94-4 formic acid ethyl ester 
• 100-61-8 N-methylaniline 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 611-21-2 N,2-dimethylaniline 
• 609-72-3 N,N-dimethyl-o-toluidine 

Relevant articles and documents

Additive-free selective methylation of secondary amines with formic acid over a Pd/In2O3 catalyst

Formic acid is used as the sole carbon and hydrogen source in the methylation of aromatic and aliphatic amines to methylamines. The reaction proceeds via a formylation/transfer hydrogenation pathway over a solid Pd/In2O3 catalyst without the need for any additive.

Ligand-protected Au4Ru2and Au5Ru2nanoclusters: Distinct structures and implications for site-cooperation catalysis

We report two ligand-protected Au4Ru2 and Au5Ru2 nanoclusters with distinct atomic-packing modes and electronic structures, both of which act as ideal model catalysts for identifying the catalytically active sites of catalysts on the nanoclusters. Au5Ru2 exhibits superior catalytic performances to Au4Ru2 for N-methylation of N-methylaniline to N-methylformanili, which is likely due to the site-cooperation catalysis of Au5Ru2. This journal is

Tetracoordinate borates as catalysts for reductive formylation of amines with carbon dioxide

We report sodium trihydroxyaryl borates as the first robust tetracoordinate organoboron catalysts for reductive functionalization of CO2. These catalysts, easily synthesized from condensing boronic acids with metal hydroxides, activate main group element-hydrogen (E-H) bonds efficiently. In contrast to BX3 type boranes, boronic acids and metal-BAr4 salts, under transition metal-free conditions, sodium trihydroxyaryl borates exhibit high reactivity of reductive N-formylation toward a variety of amines (106 examples), including those with functional groups such as ester, olefin, hydroxyl, cyano, nitro, halogen, MeS-, ether groups, etc. The over-performance to catalyze formylation of challenging pyridyl amines affords a promising alternative method to the use of traditional formylation reagents. Mechanistic investigation supports electrostatic interactions as the key for Si/B-H activation, enabling alkali metal borates as versatile catalysts for hydroborylation, hydrosilylation, and reductive formylation/methylation of CO2.