132293-93-7

Basic information

• Product Name: 2-((R)-2-Oxo-azepan-3-yl)-isoindole-1,3-dione
• Synonyms: 2-((R)-2-Oxo-azepan-3-yl)-isoindole-1,3-dione
• CAS NO: 132293-93-7
• Molecular Weight: 258.277
• Mol File: 132293-93-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-((R)-2-Oxo-azepan-3-yl)-isoindole-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-((R)-2-Oxo-azepan-3-yl)-isoindole-1,3-dione(132293-93-7)
• EPA Substance Registry System: 2-((R)-2-Oxo-azepan-3-yl)-isoindole-1,3-dione(132293-93-7)

Safety Data

• Hazardous Substances Data: 132293-93-7(Hazardous Substances Data)

Upstream product

• 22509-74-6 N-ethoxycarbonylphthalimide 
• 671-42-1 D(+)-α-Amino-ε-caprolactam 
• 21568-87-6 L(-)-α-Amino-ε-caprolactam 
• 85-44-9 phthalic anhydride 
• 28957-33-7 (R)-3-amino-azepan-2-one 

Downstream Products

• 16509-61-8 (R)-2-amino-6-hydroxy-hexanoic acid 
• 783368-48-9 C₁₃H₁₈N₂O 

Relevant articles and documents

Synthesis of bengamide E analogues and their cytotoxic activity

A series of bengamide E analogues were prepared from the corresponding polyketide chain and amino acids via amide coupling reactions. Opening of the polyketide chain lactone ring with α-aminolactams was successfully achieved under microwave irradiation in the presence of sodium 2-ethyl hexanoate. A cytotoxic activity evaluation against a panel of cancer cell lines (KB, HepG-2, Lu-1, MCF-7, HL-60 and Hela) indicated that the 2′R analogues were generally more cytotoxic than the 2′S analogues. Additionally, several analogues exhibited selective inhibition against various cancer cell lines: compounds 32a and 32b selectively inhibited MCF-7 cells, while 33b and 35b were more sensitive toward Lu-1 and HepG-2, respectively. Notably, some of the synthetic analogues possess cytotoxic activities with IC50 values less than 1?μM.