132335-49-0

Basic information

• Product Name: 2-Thiophenemethanol, a-[2-(dimethylamino)ethyl]-, (R)-
• CAS NO: 132335-49-0
• Molecular Formula: C9H15NOS
• Molecular Weight: 185.29
• Mol File: 132335-49-0.mol
• Article Data: 35

Chemical Properties

• CAS DataBase Reference: 2-Thiophenemethanol, a-[2-(dimethylamino)ethyl]-, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Thiophenemethanol, a-[2-(dimethylamino)ethyl]-, (R)-(132335-49-0)
• EPA Substance Registry System: 2-Thiophenemethanol, a-[2-(dimethylamino)ethyl]-, (R)-(132335-49-0)

Safety Data

• Hazardous Substances Data: 132335-49-0(Hazardous Substances Data)

Usage

Description

2-Thiophenemethanol, a-[2-(dimethylamino)ethyl]-, (R)is a chiral chemical compound featuring a thiophene ring connected to an alpha-(dimethylamino)ethyl side chain. It is recognized for its high selectivity and potency in biological activities, making it a significant component in the synthesis of pharmaceuticals, agrochemicals, and fine chemicals.

Uses

Used in Pharmaceutical Industry:
2-Thiophenemethanol, a-[2-(dimethylamino)ethyl]-, (R)is used as a building block for the synthesis of drugs, particularly those targeting central nervous system disorders and cancer. Its chiral nature and distinct stereochemistry allow for the development of novel compounds with improved pharmacokinetic and pharmacodynamic properties.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2-Thiophenemethanol, a-[2-(dimethylamino)ethyl]-, (R)serves as a valuable tool for drug discovery and development. Its high selectivity and potency in biological activities contribute to the creation of more effective and targeted therapeutic agents.

Upstream product

• 13636-02-7 3-(N,N-dimethylamino)-1-(thien-2-yl)propan-1-ol 
• 17199-29-0 (S)-Mandelic acid 
• 5424-47-5 3-(dimethylamino)-1-(thiophen-2-yl)propan-1-one hydrochloride 
• 88-15-3 2-Acetylthiophene 
• 13196-35-5 3-(dimethylamino)-1-(thiophen-2-yl)propan-1-one 
• 34772-98-0 3-dimethylamino-1-thiophen-2-ylpropenone 

Downstream Products

• 287737-72-8 (S)-N,N-dimethyl-N-[3-hydroxy-3-(2-thienyl)propyl]-ammonium (S)-mandelate 
• 116817-13-1 duloxetine 
• 116817-79-9 phenyl N-methyl-3-(1-naphthalenyloxy)-3-(2-thienyl)-propylcarbamate 
• 116817-12-0 N,N-dimethyl-3-(1-naphthalenyloxy)-3-(thien-2-yl)propanamine oxalate 
• 1202748-15-9 R(-)-N,N-dimethyl-3-hydroxy-3-(2-thienyl)propanamine D (-)-MA salt 
• 132335-47-8 (S)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine oxalate 
• 136434-34-9 duloxetine hydrochloride 
• 132335-46-7 N-methyl-(S)-duloxetine 
• 947686-09-1 (S)-N-methyl-N-phenoxycarbonyl-3-(1-naphthyloxy)-3-(2-thienyl)-1-propylamine 
• 1369583-87-8 N-[4-(2-methoxyphenylpiperazinyl)propionyl]-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine 
• 1369583-88-9 N-[4-(3-trifluoromethylphenylpiperazinyl)propionyl]-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine 
• 1369583-90-3 N-[4-(4-(2-methoxyphenylpiperazinyl)butyryl)]-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine 
• 1369583-91-4 N-[4-(4-(3-trifluoromethylphenylpiperazinyl)butyryl)]-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine 
• 1369583-93-6 N-[4-(2-methoxyphenylpiperazinyl)propyl]-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine 

Relevant articles and documents

Amino alcohols using the optically active amino alcohol derivative bi- Nord complex boron - -

Disclosed are an amino alcohol-boron-binol complex as an intermediate, including Complex 3-1-1 shown below, and a method for preparing an optically active amino alcohol by using the same, wherein a racemic amino alcohol is resolved in an enationselective manner using a boron compound and a (R)- or (S)-binol, whereby an amino alcohol derivative with high optical purity can be prepared at high yield.

Chiral amino-pyridine-phosphine tridentate ligand, manganese complex, and preparation method and application thereof

The invention discloses a chiral amino-pyridine-phosphine tridentate ligand, a manganese complex, and a preparation method and application thereof. The chiral amino-pyridine-phosphine tridentate ligand is shown as a formula II, and the manganese complex of the chiral amino-pyridine-phosphine tridentate ligand can be used for efficiently catalyzing and hydrogenating ketone compounds to prepare chiral alcohol compounds in a high enantioselectivity mode. The chiral amino-pyridine-phosphine tridentate ligand and the manganese complex are simple in synthesis process, good in stability, high in catalytic activity and mild in reaction conditions.

Preparation method of S-(+)duloxetine hydrochloride intermediate

The invention discloses a preparation method of a compound of a formula B (shown in the description). The preparation method comprises the steps of dissolving a compound of a formula A (shown in the description) in a solvent, and reacting under the effect of a reducing agent. Furthermore, the ee value of the compound of the formula B obtained by reducing in the presence of a complex, namely ferrocene, is over 98%. The preparation method provided by the invention is simple and feasible, the resolution or the chiral catalysis induction is not required, the product yield and the chiral purity arehigh, and the preparation method is suitable for the industrial production of S-(+)duloxetine hydrochloride intermediate.