132360-38-4

Basic information

• Product Name: 2,5-bis(4-methylphenyl)thiazole
• Synonyms: 2,5-bis(4-methylphenyl)thiazole
• CAS NO: 132360-38-4
• Molecular Weight: 265.379
• Mol File: 132360-38-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2,5-bis(4-methylphenyl)thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-bis(4-methylphenyl)thiazole(132360-38-4)
• EPA Substance Registry System: 2,5-bis(4-methylphenyl)thiazole(132360-38-4)

Safety Data

• Hazardous Substances Data: 132360-38-4(Hazardous Substances Data)

Upstream product

• 27088-83-1 2-(4-Methylphenyl)thiazole 
• 624-31-7 4-tolyl iodide 
• 288-47-1 1,3-thiazole 

Relevant articles and documents

A 2, 5 - diaryl five-membered heterocyclic aromatic preparation method

The invention relates to a 2, 5 - diaryl five-membered heterocyclic aromatic preparation method, the method is to turn the diaryl Iodized salt compounds, five-membered heterocyclic aromatic compound, catalyst, ligand, alkali and solvent are mixed uniformly, in 100 °C -140 °C lower sealing reaction for 24 hours, the reaction solution obtained after the reaction is complete; the reaction solution are often gauge extraction, drying, concentration, column chromatography separation to obtain the 2, 5 - diaryl five-membered heterocyclic aromatic compounds. The invention belongs to a pot of reaction of the atom economy, simple operation, high yield, can realize the large-scale production, in functional organic material, biological active compounds and pharmaceutical synthesis of better industrial application prospect.

Direct arylation of thiazoles on water

Wetter is better: The direct arylation of thiazoles on water is quicker, cleaner, and higher-yielding than arylation in organic solvents. The reaction works under mild conditions for an array of aryl iodides, producing 2,5-diaryl thiazoles in excellent yields. Importantly, novel bi-heteroaryl compounds are produced without the requirement for stoichiometric organometallic coupling agents. (Figure Presented).