27088-83-1

Basic information

• Product Name: 2-p-tolylthiazole
• Synonyms: 2-p-tolylthiazole
• CAS NO: 27088-83-1
• Molecular Formula: C₁₀H₉NS
• Molecular Weight: 175.2502
• Mol File: 27088-83-1.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 290.1 °C at 760 mmHg
• Flash Point: 132.3 °C
• Appearance: /
• Density: 1.14 g/cm³
• Vapor Pressure: 0.00368mmHg at 25°C
• Refractive Index: 1.593
• CAS DataBase Reference: 2-p-tolylthiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-p-tolylthiazole(27088-83-1)
• EPA Substance Registry System: 2-p-tolylthiazole(27088-83-1)

Safety Data

• Hazardous Substances Data: 27088-83-1(Hazardous Substances Data)

Usage

General Description

2-p-tolylthiazole is a chemical compound that belongs to the thiazole group. It is a heterocyclic aromatic compound that contains a five-membered ring with four carbon atoms, one sulfur atom, and a nitrogen atom. 2-p-tolylthiazole is commonly used in the synthesis of pharmaceuticals and agrochemicals. It has also been found to exhibit antimicrobial, antitumor, and anti-inflammatory properties, making it a valuable building block for the development of new drugs. Additionally, 2-p-tolylthiazole is utilized in the fabrication of organic electronic materials and as a corrosion inhibitor in industrial applications. Its versatile properties and wide range of applications make it a valuable compound in various industries.

InChI:InChI=1/C10H9NS/c1-8-2-4-9(5-3-8)10-11-6-7-12-10/h2-7H,1H3

Upstream product

• 106-49-0 p-toluidine 
• 288-47-1 1,3-thiazole 
• 36719-51-4 3,3-diethyl-1-(4-methylphenyl)-1-triazene 
• 459-44-9 4-methylbenzenediazonium tetrafluoroborate 
• 623-13-2 4-methylphenyl methylsulfide 
• 624-31-7 4-tolyl iodide 
• 104-85-8 para-methylbenzonitrile 
• 13084-31-6 2-(4-methylphenyl)-4,5-dihydro-1,3-thiazole 
• 3034-52-4 2-chlorothiazole 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 98-59-9 p-toluenesulfonyl chloride 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 
• 25563-06-8 N-methoxy-4-methylbenzamide 
• 824-79-3 sodium 4-methylbenzenesulfinate 

Downstream Products

• 1000029-33-3 2-(4-methylphenyl)-5-(4-nitrophenyl)thiazole 
• 1000029-32-2 5-(4-chlorophenyl)-2-(4-methylphenyl)thiazole 
• 132360-38-4 2,5-bis(4-methylphenyl)thiazole 
• 72997-55-8 5-(4-methoxyphenyl)-2-(4-methylphenyl)thiazole 
• 75601-35-3 2-mesitylthiazole 
• 16112-22-4 2-(4-methylphenyl)-5-phenylthiazole 
• 2227-61-4 4-phenyl-2-(4′-methylphenyl)thiazole 
• 1393673-11-4 C₂₀H₁₆N₂S₂ 
• 1393673-09-0 4-bromo-5-iodo-2-tolylthiazole 
• 1142196-28-8 4-bromo-2-tolylthiazole 
• 1086382-54-8 5-bromo-2-tolylthiazole 
• 1393673-25-0 C₄₀H₂₈N₄S₄ 
• 1393673-24-9 C₂₀H₁₄Br₂N₂S₂ 
• 1393673-23-8 2,2'-di-p-tolyl-4,4'-bithiazole 

Relevant articles and documents

Photoinduced Heterogeneous C?H Arylation by a Reusable Hybrid Copper Catalyst

Heterogeneous copper catalysis enabled photoinduced C?H arylations under exceedingly mild conditions at room temperature. The versatile hybrid copper catalyst provided step-economical access to arylated heteroarenes, terpenes and alkaloid natural products with various aryl halides. The hybrid copper catalyst could be reused without significant loss of catalytic efficacy. Detailed studies in terms of TEM, HRTEM and XPS analysis of the hybrid copper catalyst, among others, supported its outstanding stability and reusability.

Mixed N-heterocycles/N-heterocyclic carbene palladium(II) allyl complexes as precatalysts for direct arylation of azoles with aryl bromides

A series of mixed N-heterocycles/N-heterocyclic carbene palladium(II) allyl complexes with general formula [(NHC)Pd(η3-allyl)]2(μ2-N-heterocycles)(BF4)2 were prepared in one pot based on anion metathesis of (NHC)Pd(η3-allyl)Cl complexes and then ligand replacement with N-heterocycles [N-heterocycles = pyrazine (pyz), 4,4′-bipyridine (bpy) and trans-4,4′-bipyridylethylene (bpe)]. The solid-state structures shown dinuclear structures with two palladium(II) centers holding together by bridged N-heterocycles. Initially investigation of the obtained complexes as precatalysts for direct C[sbnd]H bond arylation of azoles with aryl bromides was carried out.

Palladium-Catalyzed Zinc-Amide-Mediated C-H Arylation of Fluoroarenes and Heteroarenes with Aryl Sulfides

C-H arylation of polyfluoroarenes and heteroarenes with aryl sulfides proceeds smoothly with the aid of a palladium-N-heterocyclic carbene catalyst. A bulky zinc amide, TMPZnCl an effective base to generate the corresponding arylzinc species in situ. This arylation protocol is practically much easier to perform than our previous method, which necessitates preparation of the arylzinc reagents in advance from the corresponding aryl halides. Aryl sulfides that are prepared through sulfur-specific reactions, such as SNAr sulfanylation and extended Pummerer reactions, undergo this direct arylation, offering interesting transformations that are otherwise difficult to achieve with conventional halogen-based organic synthesis.