1325235-70-8

Basic information

• Product Name: N-(3-(3-hydroxypropyl)-5-methoxyphenyl)non-8-enamide
• Synonyms: N-(3-(3-hydroxypropyl)-5-methoxyphenyl)non-8-enamide
• CAS NO: 1325235-70-8
• Molecular Weight: 319.444
• Mol File: 1325235-70-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(3-(3-hydroxypropyl)-5-methoxyphenyl)non-8-enamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-(3-hydroxypropyl)-5-methoxyphenyl)non-8-enamide(1325235-70-8)
• EPA Substance Registry System: N-(3-(3-hydroxypropyl)-5-methoxyphenyl)non-8-enamide(1325235-70-8)

Safety Data

• Hazardous Substances Data: 1325235-70-8(Hazardous Substances Data)

Upstream product

• 354512-22-4 3-methoxyl-5-nitrobenzaldehyde 
• 78238-13-8 3-methoxy-5-nitrobenzoic acid methyl ester 
• 2695-48-9 8-Bromo-1-octene 
• 5048-34-0 non-8-enenitrile 
• 1325235-65-1 ethyl 3-(3-methoxy-5-nitrophenyl)propanoate 
• 1325235-63-9 (E)-ethyl 3-(3-methoxy-5-nitrophenyl)acrylate 
• 31642-67-8 non-8-enoic acid 
• 1325235-69-5 3-(3-amino-5-methoxyphenyl)propan-1-ol 
• 1325235-67-3 C₁₀H₁₃NO₄ 
• 2702-58-1 methyl 3,5-dinitrobenzoate 

Downstream Products

• 1325235-97-9 (4R,7E)-10-(3-methoxy-5-(non-8-enamido)phenyl)-7-methyldeca-1,7-dien-4-yl (2S)-2-(cyclohexanecarboxamido)propanoate 
• 1325235-98-0 (4R,7E)-10-(3-methoxy-5-(non-8-enamido)phenyl)-7-methyldeca-1,7-dien-4-yl 2-(cyclohexanecarboxamido)acetate 
• 1325235-99-1 (4R,7E)-10-(3-methoxy-5-(non-8-enamido)phenyl)-7-methyldeca-1,7-dien-4-yl (2R)-2-acetamidopropanoate 
• 1325236-01-8 (4R,7E)-10-(3-methoxy-5-(non-8-enamido)phenyl)-7-methyldeca-1,7-dien-4-yl (2R)-2-(cyclopentanecarboxamido)propanoate 
• 1325236-02-9 (4R,7E)-10-(3-methoxy-5-(non-8-enamido)phenyl)-7-methyldeca-1,7-dien-4-yl (2R)-2-(cyclohexanecarboxamido)-3-methylbutanoate 
• 1325236-03-0 (4R,7E)-10-(3-methoxy-5-(non-8-enamido)phenyl)-7-methyldeca-1,7-dien-4-yl (2R)-2-(cyclohexanecarboxamido)-4-methylpentanoate 
• 1325236-04-1 (4R,7E)-10-(3-methoxy-5-(non-8-enamido)phenyl)-7-methyldeca-1,7-dien-4-yl (2R)-2-(cyclohexanecarboxamido)-3-phenylpropanoate 
• 1325235-75-3 (S,E)-N-(3-(7-hydroxy-4-methyldeca-3,9-dien-1-yl)-5-methoxyphenyl)non-8-enamide 
• 1325235-76-4 (R)-(R,E)-10-(3-methoxy-5-(non-8-enamido)phenyl)-7-methyldeca-1,7-dien-4-yl 2-(cyclohexanecarboxamido)propanoate 
• 1325235-78-6 (4R,7Z)-10-(3-methoxy-5-(non-8-enamido)phenyl)-7-methyldeca-1,7-dien-4-yl (2R)-2-(cyclohexanecarboxamido)propanoate 
• 1325235-93-5 N-(3-(3-iodopropyl)-5-methoxyphenyl)non-8-enamide 

Relevant articles and documents

Monoenomycin: A simplified trienomycin A analogue that manifests anticancer activity

Macrocyclic natural products are a powerful class of leadlike chemical entities. Despite commonly violating Lipinski's "rule of 5", these compounds often demonstrate superior druglike physicochemical and pharmacokinetic attributes when compared to their acyclic counterparts. However, the elaborate structural architectures of such molecules require rigorous synthetic investigation that complicates analogue development and their application to drug discovery programs. To circumvent these limitations, a conformation-based approach using limited structure-activity relationships and molecular modeling was implemented to design simplified analogues of trienomycin A, in which the corresponding analogues could be prepared in a succinct manner to rapidly identify essential structural components necessary for biological activity. Trienomycin A is a member of the ansamycin family of natural products that possesses potent anticancer activity. These studies revealed a novel trienomycin A analogue, monoenomycin, which manifests potent anticancer activity.