133044-37-8Relevant articles and documents
Structure activity relationship study of benzo[d]thiazol-2(3H)one based σ receptor ligands
Bhat, Rohit,Fishback, James A.,Matsumoto, Rae R.,Poupaert, Jacques H.,McCurdy, Christopher R.
supporting information, p. 5011 - 5013 (2013/09/02)
Herein we report the SAR study which involved structural modifications to the linker length, aryl substitution and alkylamine ring size of the benzo[d]thiazol-2(3H)one based sigma receptor (σ) ligands. Many compounds in this series displayed low nanomolar affinity for the σ receptor subtypes. In particular, 8a showed high affinity (σ-1 Ki = 4.5 nM) for σ-1 receptors and moderately high selectivity (483-fold) over σ-2 receptors.
AlCl3-DMF Reagent in the Friedel-Crafts Reaction. Application to the Acylation Reaction of 2(3H)-Benzothiazolones
Yous, Said,Poupaert, Jacques H.,Lesieur, Isabelle,Depreux, Patric,Lesieur, Daniel
, p. 1574 - 1576 (2007/10/02)
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