934-34-9Relevant articles and documents
Influenza virus replication inhibitors and uses thereof
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Paragraph 0237; 0242-0244, (2021/07/01)
The invention belongs to the field of medicines, and particularly relates to novel compounds serving as an influenza virus replication inhibitor, a preparation method thereof, a pharmaceutical composition containing the compounds and application of the compounds and the pharmaceutical composition in treatment of influenza. The compounds are compounds as shown in a formula (I) or a stereoisomer, a tautomer, a nitrogen oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or prodrugs of the stereoisomer, the tautomer, the nitrogen oxide, the solvate, the metabolite and the pharmaceutically acceptable salt of the compound as shown in the formula (I). The compounds not only can well inhibit influenza viruses, but also have lower cytotoxicity, excellent in-vivo pharmacokinetic property and the in-vivo pharmacodynamic property and good liver microsome stability.
Au@Cellulose/DFNS for synthesis of thiazolidin-2-ones from arylamines, elemental sulfur and CO2
Wei, Xingyue,Wang, Xingmin
, (2021/04/22)
Turning waste into valuable material is a remarkable phenomenon in sustainable chemistry. However, this reaction is not easy to perform due to the simultaneous employment of two low-reaction raw materials. In this study, we announce the employment of elemental sulfur and CO2 in a multi-element reaction to manufacture valuable thiazolidin-2-ones in the participation of Au@Cellulose/DFNS as a catalyst. In this method, three bonds in one reaction and functional groups with good tolerance were created. To generate the catalyst, DFNS was amended with cellulose through the click reaction and employed as a support for Au nanoparticles. Cellulose acted as both decreasing and consistency medium for Au NPs and removed the need for decreasing agent. The generated catalyst was distinguished by various techniques like XPS, TEM, TGA, SEM, ICP, and XRD analyses.
Palladium-Catalyzed Hydroxylation of Aryl Halides with Boric Acid
Song, Zhi-Qiang,Wang, Dong-Hui
supporting information, p. 8470 - 8474 (2020/11/18)
Boric acid, B(OH)3, is proved to be an efficient hydroxide reagent in converting (hetero)aryl halides to the corresponding phenols with a Pd catalyst under mild conditions. Various phenol products were obtained in good to excellent yields. This transformation tolerates a broad range of functional groups and molecules, including base-sensitive substituents and complicated pharmaceutical (hetero)aryl halide molecules.