1332527-05-5Relevant articles and documents
Optimization of a pyrazole hit from FBDD into a novel series of indazoles as ketohexokinase inhibitors
Zhang, Xuqing,Song, Fengbing,Kuo, Gee-Hong,Xiang, Amy,Gibbs, Alan C.,Abad, Marta C.,Sun, Weimei,Kuo, Lawrence C.,Sui, Zhihua
, p. 4762 - 4767 (2011/09/16)
A series of indazoles have been discovered as KHK inhibitors from a pyrazole hit identified through fragment-based drug discovery (FBDD). The optimization process guided by both X-ray crystallography and solution activity resulted in lead-like compounds with good pharmaceutical properties.
