331646-98-1Relevant articles and documents
Discovery of evodiamine derivatives as potent insecticide candidates
Liu, Jingbo,Shi, Yabing,Chen, Shuting,Li, Fengyun,Wen, Wen,Wang, Yuanhong
, (2022/04/03)
In the search for novel more effective insecticides, natural products could be used as ideal template compounds due to their good environmental compatibility, various bioactivities, unique scaffolds and mode of action. We have found that natural product evodiamine, the main active component from the fruits of Evodia rutaecarpa (Juss.) Benth, displayed obvious insecticidal activities against lepidoptera pests. To continue our research, a series of evodiamine derivatives 3a-3aa were rationally designed and synthesized. The larvicidal activities results indicated that most of target compounds displayed better efficacy than evodiamine, matrine, and rotenone against Mythimna separata, Plutella xylostella and Helicoverpa armigera, among which 3z exhibited excellent larvicidal activities (65% at 2.5 mg/L against M. separata, 75% at 1.0 mg/L against P. xylostella, and 85% 10 mg/L against H. armigera, respectively), much better than evodiamine (0%), matrine (0%), and rotenone (0%). The preliminary structure activity relationships demonstrated that the fluorine atom at the E ring of evodiamine had a positive influence on the larvicidal activity. The calcium imaging experiment studies indicated that 3z could act on the ryanodine receptor (RyR) of M. separata and was an effective calcium activator for RyR.
Benzothiazole compound and its preparation method and as the application of the hypobromous acid probe
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Paragraph 0038-0040, (2019/05/15)
The invention benzothiazole compound probe and HBrO after reacting a cyclic sulfur imines key, so that the conjugate of increased levels of the reaction system, the reaction system of the fluorescence intensity of red shifted 137 nm, the ratio of the fluo
METALLO-BETA-LACTAMASE INHIBITORS
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Page/Page column 58, (2017/04/04)
The present invention relates to compounds of formula I that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.