1334676-88-8

Basic information

• Product Name: N-(4-(tert-butyl)benzyl)benzamide
• Synonyms: N-(4-(tert-butyl)benzyl)benzamide
• CAS NO: 1334676-88-8
• Molecular Weight: 267.371
• Mol File: 1334676-88-8.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: N-(4-(tert-butyl)benzyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-(tert-butyl)benzyl)benzamide(1334676-88-8)
• EPA Substance Registry System: N-(4-(tert-butyl)benzyl)benzamide(1334676-88-8)

Safety Data

• Hazardous Substances Data: 1334676-88-8(Hazardous Substances Data)

Upstream product

• 39895-55-1 4-(1,1-dimethylethyl)-benzenemethanamine 
• 134-81-6 benzil 
• 93-89-0 benzoic acid ethyl ester 
• 55-21-0 benzamide 
• 7338-94-5 1,3-diphenyl-2-propynone 
• 614-45-9 tert-Butyl peroxybenzoate 
• 122-04-3 4-nitro-benzoyl chloride 
• 1417547-02-4 C₁₈H₂₀N₂O₃ 
• 62-23-7 4-nitro-benzoic acid 
• 939-97-9 4-tert-Butylbenzaldehyde 
• 877-65-6 p-tert-butylbenzyl alcohol 
• 100-47-0 benzonitrile 

Downstream Products

• 1417547-10-4 N-(4-(4-tert-butylbenzylcarbamoyl)phenylcarbamoyl)-2,6-difluorobenzamide 

Relevant articles and documents

Tert -Butyl Peroxybenzoate Mediated Selective and Mild N-Benzoylation of Ammonia/Amines under Catalyst- and Solvent-Free Conditions

A new protocol for the synthesis of amides from tert-butyl peroxybenzoate (TBPB) and ammonia/amines has been developed under catalyst- and solvent-free conditions. The ammonia, primary and secondary amines reacted smoothly with TBPB to furnish the corresponding primary, secondary, and tertiary amides in excellent yields. TBPB proved to be an efficient and highly chemoselective benzoylating reagent for aliphatic amines in the presence of aromatic amines/hydroxyl groups.

UV-Light-Induced N-Acylation of Amines with α-Diketones

Herein, we develop a mild method for N-acylation of primary and secondary amines with α-diketones induced by ultraviolet (UV) light. Forty-six examples with various functional groups are explored at room temperature with irradiation by three 26 W UV lamps (350-380 nm). The yield reaches 97%. The gram scale experiment product yield is 76%. Moreover, this system can be applied to the synthesis of several amino acid derivatives. Mechanistic studies show that benzoin is generated in situ from benzil under UV irradiation.

Graphene Oxide: A Metal-Free Carbocatalyst for the Synthesis of Diverse Amides under Solvent-Free Conditions

An environmentally friendly, inexpensive, carbocatalyst, graphene oxide (GO) promoted efficient, metal-free transamidation of various carboxamides with aliphatic, cyclic, and aromatic amines is demonstrated. The protocol is equally applicable to phthalimide, urea, and thioamide determining its adaptability. The oxygenated functionalities such as carbonyl (?C=O), epoxy (?O?), carboxyl (?COOH) and hydroxyl (?OH), present on graphene oxide surface impart acidic properties to the catalyst. The graphene oxide being heterogeneous in nature, work efficiently under solvent-free reaction conditions providing desired products in good to excellent yields. The one-pot synthesis of 2,3-Dihydro-5H-benzo[b]-1,4-thiazepin-4-one moiety by GO catalyzed Aza Michael addition followed by intramolecular transamidation is also described. A plausible reaction mechanistic pathway involving H-bonding is discussed. The graphene oxide can be recycled and reused up to five cycles without much loss in catalytic activity. (Figure presented.).