133544-77-1Relevant articles and documents
NQO1-activated 6 -diazyl -5 - oxo - L -n-leucine prodrug and preparation method and application thereof
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Paragraph 0078-0079, (2021/10/05)
The invention discloses NQO1-activated 6 -diazyl -5 - oxo - L - n-leucine prodrug and a preparation method and application thereof. Due to the high expression NQO1 in most tumor cells, the introduced NQO1 activated quinic acid group can achieve the tumor
Anti-tumuor agents
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Page column 22, (2010/01/30)
The invention concerns anti-tumour agents of formula (I) wherein each of R1, R2and R3has the meanings defined in the specification including hydrogen, (1-4C)alkyl, (3-4)alkenyl, (3-4C)alkynyl, amino, (1-4C)alkylamino and (
Reductive activation of conformationally-constrained, anticancer drug delivery systems
Gharat, Laxmikant,Visser, Petra,Brummelhuis, Mathijn,Guiles, Ronald,Chikhale, Prashant
, p. 444 - 456 (2007/10/03)
Redox-active substituents were used to modulate reduction potentials in conformationally-constrained, drug delivery systems. The extent of drug delivery was proportional to the degree of reductive activation, which was influenced by the electronic properties of the substituents. Such reductively-activated carrier systems can be used to achieve controlled drug delivery to bioreductive regions in hypoxic solid tumors.