265645-65-6

Basic information

• Product Name: (S)-3-{4-[Bis-(2-chloro-ethyl)-amino]-phenyl}-2-[3-(2,4-dimethyl-3,6-dioxo-cyclohexa-1,4-dienyl)-3-methyl-butyrylamino]-propionic acid methyl ester
• CAS NO: 265645-65-6
• Molecular Weight: 537.483
• Mol File: 265645-65-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-3-{4-[Bis-(2-chloro-ethyl)-amino]-phenyl}-2-[3-(2,4-dimethyl-3,6-dioxo-cyclohexa-1,4-dienyl)-3-methyl-butyrylamino]-propionic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-{4-[Bis-(2-chloro-ethyl)-amino]-phenyl}-2-[3-(2,4-dimethyl-3,6-dioxo-cyclohexa-1,4-dienyl)-3-methyl-butyrylamino]-propionic acid methyl ester(265645-65-6)
• EPA Substance Registry System: (S)-3-{4-[Bis-(2-chloro-ethyl)-amino]-phenyl}-2-[3-(2,4-dimethyl-3,6-dioxo-cyclohexa-1,4-dienyl)-3-methyl-butyrylamino]-propionic acid methyl ester(265645-65-6)

Safety Data

• Hazardous Substances Data: 265645-65-6(Hazardous Substances Data)

Upstream product

• 50442-68-7 6-hydroxy-4,4,5,7-tetramethyl-3,4-dihydrocoumarin 
• 148-82-3 L-PAM 
• 527-61-7 2,6-dimethyl-1,4-benzoquinone 
• 654-42-2 1,4-dihydroxy-2,6-dimethylbenzene 
• 62978-52-3 melphalan methyl ester hydrochloride salt 
• 133544-77-1 3-(3',6'-Dioxo-2',4'-dimethylcyclohexa-1',4'-dienyl)-3,3-dimethylpropionic acid 

Downstream Products

• 88457-23-2 (S)-2-amino-3-(4-bis(2-chloroethyl)aminophenyl)propionoic acid methyl ester 
• 133544-77-1 3-(3',6'-Dioxo-2',4'-dimethylcyclohexa-1',4'-dienyl)-3,3-dimethylpropionic acid 

Relevant articles and documents

Reductive and Bioreductive Activation is Controlled by Electronic Properties of Substituents in Conformationally-Constrained Anticancer Drug Delivery Systems

Conformationally-constrained, anticancer drug delivery systems (TDDS) containing the methyl ester of melphalan (as a model drug) were synthesized using electron-withdrawing or electron-donating functional groups to modulate reductive and bioreductive activation. The electronic nature of substituents in TDDS was found to control reductive and bioreductive activation of TDDS, thus influencing drug delivery from TDDS.