1336982-58-1Relevant articles and documents
Small molecule receptor protein tyrosine phosphatase γ (RPTPγ) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop
Sheriff, Steven,Beno, Brett R.,Zhai, Weixu,Kostich, Walter A.,McDonnell, Patricia A.,Kish, Kevin,Goldfarb, Valentina,Gao, Mian,Kiefer, Susan E.,Yanchunas, Joseph,Huang, Yanling,Shi, Shuhao,Zhu, Shirong,Dzierba, Carolyn,Bronson, Joanne,MacOr, John E.,Appiah, Kingsley K.,Westphal, Ryan S.,O'Connell, Jonathan,Gerritz, Samuel W.
, p. 6548 - 6562 (2011/12/03)
Protein tyrosine phosphatases (PTPs) catalyze the dephosphorylation of tyrosine residues, a process that involves a conserved tryptophan-proline- aspartate (WPD) loop in catalysis. In previously determined structures of PTPs, the WPD-loop has been observe
