33045-52-2Relevant articles and documents
Preparation method of 2-methoxy-5-sulfamoylbenzoic acid
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Paragraph 0016; 0018-0019; 0024-0025, (2020/05/14)
The invention provides a preparation method of 2-methoxy-5-sulfamoylbenzoic acid, comprising the following steps: carrying out bromination reaction on 4-methoxybenzenesulfonamide and bromine under theaction of a reducing agent to obtain 3-bromo-4-methoxybenzenesulfonamide; carrying out substitution reaction on 3-bromo-4-methoxybenzenesulfonamide and cuprous cyanide under the action of a catalystto generate 3-cyano-4-methoxybenzenesulfonamide; carrying out alcoholysis on the 3-cyano-4-methoxybenzenesulfonamide and methanol under the catalysis of an acid to obtain 2-methoxy-5-sulfonamide methyl benzoate; hydrolyzing 2-methoxy-5-sulfonamide methyl benzoate under an alkaline condition, and then acidifying to obtain the 2-methoxy-5-sulfamoylbenzoic acid. The preparation method of the 2-methoxy-5-sulfamoylbenzoic acid is mild in reaction condition, simple in process and equipment, convenient to operate and environmentally friendly.
Method for conveniently synthesizing 2-methoxy-5-sulfamoyl methyl benzoate
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Paragraph 0018, (2016/11/07)
The invention provides a method for conveniently synthesizing 2-methoxy-5-sulfamoyl methyl benzoate. The method comprises the following steps: adding 2-methoxyl-5-chloro methyl benzoate and sodium aminosulfinic acid in a molar ratio of 1: (1 to 1.1) as well as a solvent and a catalyst into a reaction device, controlling the temperature at 40 to 65 DEG C, and reacting for 12 to 18 hours; after the reaction is ended, adding activated carbon to perform decoloring, and filtering to remove the activated carbon, catalyst and side product sodium chloride; decompressing and concentrating filtrate to obtain the 2-methoxy-5-sulfamoyl methyl benzoate. The method for conveniently synthesizing the 2-methoxy-5-sulfamoyl methyl benzoate has the advantages that the technical flow is short, the yield is high, the quality is good, the three wastes (waste gas, waste water and industrial residue) polluting the environment are avoided, and the method is environment-friendly and suitable for the industrialized mass production.
Method for synthesizing 2-methoxy-5-sulfamoylmethyl benzoate
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Paragraph 0018, (2016/11/14)
The invention provides a method for synthesizing 2-methoxy-5-sulfamoyl methyl benzoate. The method comprises the following steps: adding 2-methoxy-5-chlorobenzene methyl formate and sodium aminosulfinate at the mol ratio of 1:1.05-1.2 and a solvent and a catalyst into a reactor, controlling temperature at 40-65 DEG C and reacting for 8-16 h; carrying out decoloration by adding active carbon after the reaction, filtering to remove active carbon, the catalyst and a by-product sodium chloride; and carrying out vacuum concentration on a filtrate so as to obtain 2-methoxy-5-sulfamoyl methyl benzoate. The method for synthesizing 2-methoxy-5-sulfamoyl methyl benzoate has advantages of short original process flow, high yield and good quality. In addition, ''three wastes (waste gas, waste water and industrial residue)'' which pollute the environment are not generated. The method is very environmentally friendly and is suitable for large-scale industrial production.