22117-84-6

Basic information

• Product Name: Benzenesulfonamide, 3-cyano-4-methoxy-
• Synonyms: 2-Methoxy-5-sulfamidobenzonitril;2-Methoxy-5-sulfamoylbenzonitril;3-Cyano-4-methoxy-benzenesulfonamide
• CAS NO: 22117-84-6
• Molecular Formula: C8H8N2O3S
• Molecular Weight: 212.229
• Mol File: 22117-84-6.mol
• Article Data: 1

Chemical Properties

• Melting Point: 173 °C
• CAS DataBase Reference: Benzenesulfonamide, 3-cyano-4-methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, 3-cyano-4-methoxy-(22117-84-6)
• EPA Substance Registry System: Benzenesulfonamide, 3-cyano-4-methoxy-(22117-84-6)

Safety Data

• Hazardous Substances Data: 22117-84-6(Hazardous Substances Data)

Upstream product

• 23095-03-6 3-bromo-4-methoxybenzenesulfonamide 

Downstream Products

• 33045-52-2 methyl 2-methoxy-5-sulfamoyl-benzoate 

Relevant articles and documents

Preparation method of 2-methoxy-5-sulfamoylbenzoic acid

The invention provides a preparation method of 2-methoxy-5-sulfamoylbenzoic acid, comprising the following steps: carrying out bromination reaction on 4-methoxybenzenesulfonamide and bromine under theaction of a reducing agent to obtain 3-bromo-4-methoxybenzenesulfonamide; carrying out substitution reaction on 3-bromo-4-methoxybenzenesulfonamide and cuprous cyanide under the action of a catalystto generate 3-cyano-4-methoxybenzenesulfonamide; carrying out alcoholysis on the 3-cyano-4-methoxybenzenesulfonamide and methanol under the catalysis of an acid to obtain 2-methoxy-5-sulfonamide methyl benzoate; hydrolyzing 2-methoxy-5-sulfonamide methyl benzoate under an alkaline condition, and then acidifying to obtain the 2-methoxy-5-sulfamoylbenzoic acid. The preparation method of the 2-methoxy-5-sulfamoylbenzoic acid is mild in reaction condition, simple in process and equipment, convenient to operate and environmentally friendly.