1338226-05-3Relevant articles and documents
A Robust Kilo-Scale Synthesis of Doravirine
Campeau, Louis-Charles,Chen, Qinghao,Gauvreau, Danny,Girardin, Mélina,Belyk, Kevin,Maligres, Peter,Zhou, Guoyue,Gu, Chaozhan,Zhang, Wei,Tan, Lushi,O'Shea, Paul D.
, p. 1476 - 1481 (2016/08/30)
Doravirine is non-nucleoside reverse transcriptase inhibitor (NNRTI) currently in phase III clinical trials for the treatment of HIV infection. Herein we describe a robust kilo-scale synthesis for its manufacture. The structure and origin of major impurit
NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
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, (2011/10/13)
Heteroaromatic compounds of Formula I: are HIV reverse transcriptase inhibitors, wherein R1, R2, R3, R4 and R5 are defined herein. The compounds of Formula I and their pharmaceutically acceptable salt