13426-94-3

Basic information

• Product Name: N-Methylbenzylamine Hydrochloride
• Synonyms: N-Methylbenzylamine Hydrochloride
• CAS NO: 13426-94-3
• Molecular Formula: C₈H₁₂N*Cl
• Molecular Weight: 158
• Mol File: 13426-94-3.mol
• Article Data: 11

Chemical Properties

• Melting Point: 173-174ºC
• Boiling Point: 180.5 °C at 760 mmHg
• Flash Point: 77.8 °C
• Appearance: /
• Water Solubility: Water Solubility (%): Soluble
• CAS DataBase Reference: N-Methylbenzylamine Hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: N-Methylbenzylamine Hydrochloride(13426-94-3)
• EPA Substance Registry System: N-Methylbenzylamine Hydrochloride(13426-94-3)

Safety Data

• Hazardous Substances Data: 13426-94-3(Hazardous Substances Data)

Usage

Description

N-Methylbenzylamine Hydrochloride is an organic compound that serves as an intermediate in the synthesis of various pharmaceutical compounds. It is a derivative of benzylamine with a methyl group attached to the nitrogen atom and a hydrochloride counterion, which contributes to its reactivity and utility in chemical reactions.

Uses

Used in Pharmaceutical Industry:
N-Methylbenzylamine Hydrochloride is used as a synthetic intermediate for the production of a metabolite of Tramadol (T712500), an analgesic. It plays a crucial role in the development of pain-relieving medications, contributing to the effectiveness and management of pain in patients.
As an intermediate, N-Methylbenzylamine Hydrochloride is essential in the synthesis of various pharmaceutical compounds, which may have applications in different areas of medicine, such as pain management, central nervous system disorders, and other therapeutic uses. Its versatility in chemical reactions and ability to form derivatives make it a valuable component in the development of new drugs and therapies.

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Downstream Products

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Relevant articles and documents

Iron-Catalyzed Reductive Amination of Aldehydes in Isopropyl Alcohol/Water Media as Hydrogen Sources

Reductive amination can be carried in i-PrOH/H2O as hydrogen sources using commercially available iron carbonyl complexes. Within an aqueous alkaline environment, a hydridocarboferrate is formed and its reducing potential is exploited for hydrogenation of the imine (or iminium ion) obtained in situ from aldehydes or ketones, and primary or secondary amines in almost equimolar ratio. This completely sustainable and hydrogen-free process proceeds at 100 °C using Fe3(CO)12 as catalyst precursor under convectional heating while Fe2(CO)9 gave better results when the reaction was carried out under MW dielectric heating. Both enolizable and non-enolizable aldehydes may be successfully employed in reactions with aliphatic and aromatic amines. (Figure presented.).

Method for preparing amine compound by reducing amide compound

The invention relates to a method for preparing an amine compound by reducing an amide compound, which comprises the following steps: in a protective atmosphere, mixing the amide compound or cyclic amide, a zirconium metal catalyst and pinacol borane, carrying out amide reduction reaction at room temperature, and carrying out aftertreatment by using an ether solution of hydrogen chloride after 12-48 hours to obtain an amine hydrochloride compound. The method is simple to operate, low in cost, good in functional group tolerance and wide in substrate range.

N-Methylation and Trideuteromethylation of Amines via Magnesium-Catalyzed Reduction of Cyclic and Linear Carbamates

A new reduction of carbamates to N-methyl amines is presented. The magnesium-catalyzed reduction reaction allows the conversion of cyclic and linear carbamates, including N-Boc protected amines, into the corresponding N-methyl amines and amino alcohols which are of significant interest due to their presence in many biologically active molecules. Furthermore, the reduction can be extended to the formation of N-trideuteromethyl labeled amines.