1753-50-0

Basic information

• Product Name: 5-Pyrimidinecarbonitrile, 2-chloro- (7CI,8CI)
• Synonyms: 5-Pyrimidinecarbonitrile, 2-chloro- (7CI,8CI);5-Pyrimidinecarbonitrile, 2-chloro-;2-Chloro-5-pyrimidinecarbonitrile;2-Chloro-5-pyriMidinecarb...;2-Chloro-5-pyriMidinecarbonitril
• CAS NO: 1753-50-0
• Molecular Formula: C₅H₂ClN₃
• Molecular Weight: 139.54248
• Product Categories: PYRIMIDINE;Heterocycle-Pyrimidine series
• Mol File: 1753-50-0.mol
• Article Data: 6

Chemical Properties

• Melting Point: 130-132 °C
• Boiling Point: 331.279 °C at 760 mmHg
• Flash Point: 154.152 °C
• Appearance: /
• Density: 1.438 g/cm³
• Vapor Pressure: 0.000157mmHg at 25°C
• Refractive Index: 1.568
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -4.13±0.22(Predicted)
• CAS DataBase Reference: 5-Pyrimidinecarbonitrile, 2-chloro- (7CI,8CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Pyrimidinecarbonitrile, 2-chloro- (7CI,8CI)(1753-50-0)
• EPA Substance Registry System: 5-Pyrimidinecarbonitrile, 2-chloro- (7CI,8CI)(1753-50-0)

Safety Data

• Hazardous Substances Data: 1753-50-0(Hazardous Substances Data)

Usage

General Description

5-Pyrimidinecarbonitrile, 2-chloro- (7CI,8CI) is a chemical compound that derives from pyrimidine, a type of heterocyclic aromatic organic compound. It is also known as 2-chloropyrimidine-5-carbonitrile. 5-Pyrimidinecarbonitrile, 2-chloro- (7CI,8CI) bears a highly reactive chlorine atom in its structure, making it ideal for chemical synthesis or production of some pharmaceutical drugs. Pyrimidine derivatives are often used in therapeutic drugs, particularly antiviral and anticancer medicines. However, specific information about this compound's uses or properties might fall under proprietary or confidential research. Therefore, it is critical to handle this chemical with care due to its reactivity and potential bioactivity.

InChI:InChI=1/C5H2ClN3/c6-5-8-2-4(1-7)3-9-5/h2-3H

Upstream product

• 38373-47-6 2-methoxypyrimidine-5-carbonitrile 
• 33458-27-4 ethyl 2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 110099-99-5 2-CHLOROPYRIMIDINE-5-CARBONYLCHLORIDE 
• 856595-94-3 2-chloropyrimindine-5-carboxaminde 
• 374068-01-6 2-bromopyrimidine-5-carboxylic acid 
• 95928-49-7 ethyl 2-oxo-1,2-dihydropyrimidine-5-carboxylate 
• 89793-12-4 ethyl 2-chloropyrimidine-5-carboxylate 
• 1753-48-6 2-aminopyrimidine-5-carbonitrile 

Downstream Products

• 1057677-49-2 2-[4-(4-benzyl-phthalazin-1-yl)-piperazin-1-yl]-pyrimidine-5-carbonitrile 
• 1356542-27-2 2-but-3-ynyloxypyrimidine-5-carbonitrile 
• 1245079-23-5 [(3R,4S)-1-(5-cyanopyrimidin-2-yl)-4-(2,5-difluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester 
• 13426-94-3 N-methylbenzylamine hydrochloride 

Relevant articles and documents

Preparation method of 2-chloro-5-cyanopyrimidine compound

The invention discloses a preparation method of a 2-chloro-5-cyanopyrimidine compound. A route adopted by the preparation method is as follows: cyanoacetic acid is used as a raw material, ioxane is used as a solvent, and a reaction is conducted under the action of N,N-dimethylformamide dimethyl acetal so as to generate 3-(dimethylamino)acrylonitrile, and then a Vilsmeier reaction, an addition reaction, a ring closing reaction and a chlorination reaction are sequentially carried out to finally obtain a finished product, i.e., the 2-chloro-5-cyanopyrimidine compound. According to the synthetic route provided by the preparation method, raw materials are cheap and easily available; aftertreatment is simple; purification is easy; column chromatographic purification is not needed in each step ofreaction; the method can effectively overcome the technical defects of long route, expensive raw material cost, need of column chromatography and the like of other synthesis methods in the prior art;and the preparation method of the 2-chloro-5-cyanopyrimidine compound provided by the invention has important economic benefits on reduction of the drug cost, and is a technology which is low in costand suitable for industrial production.

ORGANIC FLUORESCENT LUMINESCENT MATERIAL AND ORGANIC ELECTROLUMINESCENT DEVICE

An organic fluorescent luminescent material and an organic electro-luminescence device are provided. The organic fluorescent luminescent material may be represented by the formula, (Ar)-(Ph)-(X), wherein Ar is Ph include at least one benzene ring, X is a six-membered aromatic ring, and at least one nitrogen atom is located on the six-membered aromatic ring. The organic fluorescent luminescent material can be used in organic electro-luminescence devices.

PYRIDONE AND PYRIDAZONE ANALOGUES AS GPR119 MODULATORS

Novel compounds of structure Formula (I) or an enantiomer, a diastereomer, or a pharmaceutically acceptable salt thereof, wherein Z, R1, R2, R21, T1, T2, T3 and T4 are defined herein, are provided which are GPR119 G protein-coupled receptor modulators. GPR119 G protein-coupled receptor modulators are useful in treating, preventing, or slowing the progression of diseases requiring GPR119 G protein-coupled receptor modulator therapy. Thus, the disclosure also concerns compositions comprising these novel compounds and methods of treating diseases or conditions related to the activity of the GPR119 G protein-coupled receptor by using any of these novel compounds or a composition comprising any of such novel compounds.