13433-09-5 Usage
Description
H-ASP-PHE-OH, also known as L-Aspartyl-L-phenylalanine, is a dipeptide formed from L-alpha-aspartyl and L-phenylalanine residues. It is obtained after the hydrolysis of aspartame in the intestinal lumen and is an impurity of Thiamine (T344185), referred to as Thiamine Impurity B. This white powder dipeptide has unique chemical properties that may be of interest in various applications.
Uses
Used in Pharmaceutical Industry:
H-ASP-PHE-OH is used as a research compound for understanding its properties and potential effects in the pharmaceutical industry. As an impurity of Thiamine, studying this dipeptide can provide insights into the synthesis, purification, and quality control processes of Thiamine and related compounds.
Used in Nutritional Research:
In the field of nutritional research, H-ASP-PHE-OH is utilized to investigate the metabolic pathways and effects of aspartame, a widely used artificial sweetener. Understanding the hydrolysis process and the role of this dipeptide can contribute to the development of healthier and safer sweetening alternatives.
Used in Quality Control and Analysis:
H-ASP-PHE-OH serves as a reference material in quality control and analysis for industries producing or utilizing Thiamine and aspartame. Its distinct chemical properties allow for accurate identification, measurement, and monitoring of impurities, ensuring product safety and efficacy.
Check Digit Verification of cas no
The CAS Registry Mumber 13433-09-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,4,3 and 3 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 13433-09:
(7*1)+(6*3)+(5*4)+(4*3)+(3*3)+(2*0)+(1*9)=75
75 % 10 = 5
So 13433-09-5 is a valid CAS Registry Number.
InChI:InChI=1/C13H16N2O5/c14-9(7-11(16)17)12(18)15-10(13(19)20)6-8-4-2-1-3-5-8/h1-5,9-10H,6-7,14H2,(H,15,18)(H,16,17)(H,19,20)/p-1/t9-,10-/m0/s1
13433-09-5Relevant articles and documents
Investigations on the degradation of aspartame using high-performance liquid chromatography/tandem mass spectrometry
Sun, Jie-Ping,Han, Qiang,Zhang, Xiao-Qiong,Ding, Ming-Yu
, p. 1259 - 1264 (2014/11/07)
Aspartame is a widely used sweetener, the long-term safety of which has been controversial ever since it was accepted for human consumption. It is unstable and can produce some harmful degradation products under certain storage conditions. A high-performa
Increased stability of peptidesulfonamide peptidomimetics towards protease catalyzed degradation
De Bont, Dries B.A.,Sliedregt-Bol, Karen M.,Hofmeyer, Lovina J. F.,Liskamp, Rob M. J.
, p. 1043 - 1047 (2007/10/03)
Replacement of amide bonds in peptides by sulfonamide moieties resulted in peptidosulfonamides with an increased stability towards protease catalyzed degradation. In addition to protection of the protease cleavage site, it was found that introduction of a sulfonamide also influenced the stability of adjacent amide bonds. Copyright (C) 1999 Elsevier Science Ltd.
Preparation process of α-l-aspartyl-l-phenyl-alanine methyl ester or hydrohalide thereof
-
, (2008/06/13)
α-L-aspartyl-L-phenylalanine methyl ester or the hydrohalide thereof is prepared by esterifying α-L-aspartyl-L-phenylalanine or α-L-aspartyl-L-phenylalanine which has been formed in situ by treating an N-protected-α-L-aspartyl-L-phenylalanine in an aqueou
