1343471-61-3

Basic information

• Product Name: rac-3-(dimethylamino)-1-(3-hydroxyphenyl)-2-methylpropan-1-one
• Synonyms: rac-3-(dimethylamino)-1-(3-hydroxyphenyl)-2-methylpropan-1-one
• CAS NO: 1343471-61-3
• Molecular Weight: 207.272
• Mol File: 1343471-61-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: rac-3-(dimethylamino)-1-(3-hydroxyphenyl)-2-methylpropan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: rac-3-(dimethylamino)-1-(3-hydroxyphenyl)-2-methylpropan-1-one(1343471-61-3)
• EPA Substance Registry System: rac-3-(dimethylamino)-1-(3-hydroxyphenyl)-2-methylpropan-1-one(1343471-61-3)

Safety Data

• Hazardous Substances Data: 1343471-61-3(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 13103-80-5 1-(3-hydroxyphenyl)propan-1-one 
• 506-59-2 N,N-dimethylammonium chloride 

Downstream Products

• 1369205-94-6 toluene-4-sulfonic acid 3-(3-dimethylamino-2-methylpropionyl)phenyl ester 
• 515114-52-0 (±)-3-(1-(dimethylamino)-2-methylpentan-3-yl)phenol 
• 175591-09-0 3-(3-dimethylamino-1-ethyl-2-methylpropyl)phenol hydrochloride 
• 175591-09-0 tapentadol hydrochloride 
• 175591-23-8 tapentadol 
• 1369205-95-7 [2S]-toluene-4-sulfonic acid 3-(3-dimethylamino-2-methylpropionyl)phenyl ester 
• 1369205-98-0 [2R]-toluene-4-sulfonic acid 3-(3-dimethylamino-2-methyl-propionyl)-phenyl ester L-dibenzoyl tartaric acid salt 
• 1369205-97-9 dibenzoyl-L-tartaric acid [2S]-toluene-4-sulfonic acid 3-(3-dimethylamino-2-methylpropionyl)phenyl ester 
• 1369205-82-2 [2S,3RS]-toluene-4-sulfonic acid 3-(3-dimethylamino-1-ethyl-1-hydroxy-2-methylpropyl)phenyl ester 
• 1369206-01-8 [2S,3RS]-toluene-4-sulfonic acid 3-(3-dimethylamino-1-ethyl-1-hydroxy-2-methylpropyl)phenyl ester hydrochloride 
• 1369205-83-3 toluene-4-sulfonic acid 3-[1-(2-dimethylamino-1-methylethyl)propenyl]phenyl ester 
• 1369206-03-0 (1R)-toluene-4-sulfonic acid 3-[1-(2-dimethylamino-1-methylethyl)propenyl]phenyl ester 
• 1369205-85-5 [1R,2R]-toluene-4-sulfonic acid 3-(3-dimethylamino-1-ethyl-2-methylpropyl)phenyl ester 
• 1369205-81-1 toluene-4-sulfonic acid 3-(3-dimethylamino-1-ethyl-1-hydroxy-2-methylpropyl)phenyl ester 

Relevant articles and documents

NOVEL PROCESS FOR PREPARING HIGHLY PURE TAPENTADOL OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF

Provided herein is a novel, commercially viable and industrially advantageous process for the preparation of 3-[(1R,2R)-3-(dimethylamino)-1-ethyl-2-methylpropyl]phenol (Tapentadol), or a pharmaceutically acceptable salt thereof, and its intermediates, in high yield and purity. Provided also herein are novel solid state forms of tapentadol intermediates and processes for their preparation thereof. Provided further herein is a purification process for preparing highly pure tapentadol hydrochloride.

PROCESS FOR PREPARING L-PHENYL-3-DIMETHYLAMINOPROPANE DERIVATIVE

Provided is a process for the preparing l-phenyl-3-dimethylaminopropane derivatives of formula I, (The formula should be inserted here) and its pharmaceutically acceptable salts thereof via novel intermediates.