1343494-43-8

Basic information

• Product Name: (R)-1-benzyl 7-methyl 5-(tert-butyldimethylsilyloxy)-3-oxoheptanedioate
• Synonyms: (R)-1-benzyl 7-methyl 5-(tert-butyldimethylsilyloxy)-3-oxoheptanedioate
• CAS NO: 1343494-43-8
• Molecular Weight: 408.567
• Mol File: 1343494-43-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-1-benzyl 7-methyl 5-(tert-butyldimethylsilyloxy)-3-oxoheptanedioate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-benzyl 7-methyl 5-(tert-butyldimethylsilyloxy)-3-oxoheptanedioate(1343494-43-8)
• EPA Substance Registry System: (R)-1-benzyl 7-methyl 5-(tert-butyldimethylsilyloxy)-3-oxoheptanedioate(1343494-43-8)

Safety Data

• Hazardous Substances Data: 1343494-43-8(Hazardous Substances Data)

Usage

Description

(R)-1-benzyl 7-methyl 5-(tert-butyldimethylsilyloxy)-3-oxoheptanedioate is a complex organic molecule characterized by its chiral nature, featuring a benzyl group, a methyl group, and a tert-butyldimethylsilyloxy group attached to a heptanedioate backbone. This specific (R)-enantiomer is distinguished by its unique configuration and holds potential for various applications in pharmaceuticals and organic chemistry.

Uses

Used in Pharmaceutical Applications:
(R)-1-benzyl 7-methyl 5-(tert-butyldimethylsilyloxy)-3-oxoheptanedioate is used as a pharmaceutical candidate for drug design and synthesis due to its unique structure and functional groups, which can be exploited to create novel therapeutic agents.
Used in Organic Chemistry:
In the field of organic chemistry, (R)-1-benzyl 7-methyl 5-(tert-butyldimethylsilyloxy)-3-oxoheptanedioate is used as a reagent or building block for the synthesis of other complex molecules, taking advantage of its versatile molecular framework and functional groups.
Used in Chemical Synthesis Industry:
(R)-1-benzyl 7-methyl 5-(tert-butyldimethylsilyloxy)-3-oxoheptanedioate is used as a key intermediate in the synthesis of various complex organic compounds, particularly in the development of new pharmaceuticals and advanced materials.
Used in Research and Development:
(R)-1-benzyl 7-methyl 5-(tert-butyldimethylsilyloxy)-3-oxoheptanedioate is also utilized in research and development settings to study its properties, reactivity, and potential applications in creating new molecules with specific biological activities or material properties.

Upstream product

• 40204-26-0 malonic acid monobenzyl ester 
• 1343494-42-7 (R)-3-((tert-butyldimethylsilyl)oxy)-5-(1H-imidazol-1-yl)-5-oxopentanoate methyl ester 

Downstream Products

• 147526-32-7 pitavastatin calcium salt 
• 147526-32-7 pitavastatin 
• 849811-78-5 methyl (3R,5S,6E)-7-{2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl}-3,5-dihydroxyhept-6-enoate 
• 1213706-08-1 (3R,5S,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoic acid (R)-NEA salt 
• 182075-76-9 (R,E)-methyl 3-(tert-butyldimethylsilyloxy)-7-(2-cyclopropyl-4-(-4-fluorophenyl)-quinolin-3-yl)-5-oxohept-6-enoate 

Relevant articles and documents

PROCESS FOR PREPARING STATINS

Process for the preparation of β-ketoester synthetic intermediates useful in the preparation of statins, in particular Pitavastatin.