134404-41-4

Basic information

• Product Name: (5Z,7E,22E)-(1S,3R)-1,3-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-9,10-secochola-5,7,10⁽¹⁹⁾,22-tetraen-24-al
• Synonyms: (5Z,7E,22E)-(1S,3R)-1,3-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-9,10-secochola-5,7,10⁽¹⁹⁾,22-tetraen-24-al
• CAS NO: 134404-41-4
• Molecular Weight: 599.057
• Mol File: 134404-41-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (5Z,7E,22E)-(1S,3R)-1,3-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-9,10-secochola-5,7,10⁽¹⁹⁾,22-tetraen-24-al(CAS DataBase Reference)
• NIST Chemistry Reference: (5Z,7E,22E)-(1S,3R)-1,3-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-9,10-secochola-5,7,10⁽¹⁹⁾,22-tetraen-24-al(134404-41-4)
• EPA Substance Registry System: (5Z,7E,22E)-(1S,3R)-1,3-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-9,10-secochola-5,7,10⁽¹⁹⁾,22-tetraen-24-al(134404-41-4)

Safety Data

• Hazardous Substances Data: 134404-41-4(Hazardous Substances Data)

Upstream product

• 134404-40-3 (5Z,7E,22E)-(1S,3R)-1,3-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-9,10-secochola-5,7,10⁽¹⁹⁾,22-tetraen-24-ol 
• 112924-91-1 (5Z,7E)-(1S,3R,20S)-1,3-bis<(tert-butyldimethylsilyl)oxy>-9,10-seco-22,23-dinor-5,7,10(19)-cholatrien-24-al 
• 112828-13-4 (5E,7E)-(1S,3R,20S)-1,3-bis<<(1,1-dimethylethyl)dimethylsilyl>oxy>-20-methyl-9,10-secopregna-5,7,10(19)-trien-21-al 
• 134404-39-0 methyl (5Z,7E,22E)-(1S,3R)-1,3-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-9,10-secochola-5,7,10⁽¹⁹⁾,22-tetraen-24-oate 

Downstream Products

• 227747-77-5 diethyl (5Z,7E,22E,24E)-(1S,3R)-[1,3-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-24a-homo-9,10-secochola-5,7,10⁽¹⁹⁾,22,24-pentaen-24a-yl]phosphonate 
• 227747-89-9 tetraethyl (5Z,7E,22E)-(1S,3R)-[1,3-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-24a-homo-9,10-secochola-5,7,10⁽¹⁹⁾,22,24-pentaene-24a,24a-diyl]bisphosphonate 
• 227747-87-7 tetraethyl (5Z,7E,22E,24E)-(1S,3R)-[1,3-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-24-nor-9,10-secocholesta-5,7,10⁽¹⁹⁾,22-tetraene-26,27-diyl]bisphosphonate 
• 198760-31-5 (5Z,7E,22E)-(1S,3R,24R)-25-(5-butyloxazole-2-yl)-26,27-cyclo-9,10-secocholesta-5,7,10⁽¹⁹⁾,22-tetraene-1,3,24-triol 
• 198760-27-9 (5Z,7E,22E)-(1S,3R,24R)-25-(4-ethyloxazol-2-yl)-26,27-cyclo-9,10-secocholesta-5,7,10⁽¹⁹⁾,22-tetraene-1,3,24-triol 
• 198760-28-0 (5Z,7E,22E)-(1S,3R,24R)-25-(4-propyloxazol-2-yl)-26,27-cyclo-9,10-secocholesta-5,7,10⁽¹⁹⁾,22-tetraene-1,3,24-triol 
• 198760-48-4 (5Z,7E,22E)-(1S,3R,24R)-25-(6-methyl-pyridin-2-yl)-26,27-cyclo-9,10-secocholesta-5,7,10⁽¹⁹⁾,22-tetraene-1,3,24-triol 
• 198760-04-2 (5Z,7E,22E)-(1S,3R,24R)-25-(4-butylthiazol-2-yl)-26,27-cyclo-9,10-secocholesta-5,7,10⁽¹⁹⁾,22-tetraene-1,3,24-triol 
• 198760-02-0 ZK 191732 
• 198760-03-1 (5Z,7E,22E)-(1S,3R,24R)-25-(4-propylthiazol-2-yl)-26,27-cyclo-9,10-secocholesta-5,7,10⁽¹⁹⁾,22-tetraene-1,3,24-triol 
• 198760-36-0 (5Z,7E,22E)-(1S,3R,24R)-25-(5-ethylthiazol-2-yl)-26,27-cyclo-9,10-secocholesta-5,7,10⁽¹⁹⁾,22-tetraene-1,3,24-triol 
• 198759-99-8 (5Z,7E,22E)-(1S,3R,24R)-25-(5-Pentyloxazole-2-yl)-26,27-cyclo-9,10-secocholesta-5,7,10⁽¹⁹⁾,22-tetraene-1,3,24-triol 
• 198759-98-7 (5Z,7E,22E)-(1S,3R,24R)-25-(5-Ethyloxazole-2-yl)-26,27-cyclo-9,10-secocholesta-5,7,10⁽¹⁹⁾,22-tetraene-1,3,24-triol 

Relevant articles and documents

Synthesis and biological activities of a new series of secosteroids: vitamin D phosphonate hybrids

By a structural combination of phosphonate and bisphosphonate moieties with the vitamin D skeleton a series of new vitamin D analogs was synthesized. Derivatives with 24β-hydroxy- or 24-keto groups exerted considerable vitamin D activities in vitro while the hypercalcemic potentials were significantly reduced as compared to 1α,25-dihydroxyvitamin D3 (calcitriol). Whereas the 24-hydroxy analogs did not influence bone formation in vivo in dosages below the hypercalcemic threshold, the 24-ketones were found to induce synthesis of new bone matrix in non-hypercalcemic doses. Vitamin D bisphosphonate hybrids, on the other hand, which did not elicit substantial vitamin D activities in vitro and tend to decrease serum calcium levels in vivo clearly induced osteoid formation in rats, indicating a mechanism of action different to calcitriol. Copyright