112828-13-4Relevant articles and documents
Enantiomeric impurity PY2 of tacalcitol and preparation method and application thereof
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, (2018/05/30)
The invention discloses an enantiomeric impurity PY2 of tacalcitol, i.e., (1 alpha, 3 beta, 5Z, 7E, 24S)-9,10-Secocholesta-5,7,10(19)-triene-1,3,24-triol, and a preparation method thereof, and belongsto the technical field of chemical pharmaceutical. The high-purity relevant impurity PY2 of the tacalcitol, which is disclosed by the invention, can be used as an impurity standard substance in the tacalcitol finished product detection analysis so as to promote accurate positioning and nature determination of the tacalcitol finished product detection analysis on the impurity and benefit reinforcement of control on the impurity, thereby improving quality of a tacalcitol finished product. The method provided by the invention has the advantages that the raw materials are cheap and easy to obtain, the operation is simple, the reproducibility is good in and the HPLC (High Performance Liquid Chromatography) purity is greater than or equal to 99.5%.
Synthesis and biological evaluation of a new vitamin D2 analogue
Gandara, Zoila,Perez, Manuel,Salomon, Debora G.,Ferronato, Maria J.,Fermento, Maria E.,Curino, Alejandro C.,Facchinetti, Maria M.,Gomez, Generosa,Fall, Yagamare
, p. 6276 - 6279 (2012/10/30)
A new vitamin D2 analogue was synthesized using the Julia-Kocienski olefination. It has antiproliferative effects on cell lines from squamous cell carcinomas of colon and head and neck, but is also as hypercalcaemic as calcitriol in vivo.
Synthesis of a Biologically Active Vitamine-D2 Metabolite
Choudhry, Satish C.,Belica, Peter S.,Coffen, David L.,Focella, Antonino,Maehr, Hubert,et al.
, p. 1496 - 1500 (2007/10/02)
The synthesis of 1α,25,28-trihydroxyvitamin-D2 (1) from vitamin-D2 is described.Approaches to the upper side-chain synthon via the chiral sulfone 15, prepared either through the enzymatic resolution of 10 or the opening of the optica