87417-26-3Relevant articles and documents
An improved synthesis of 24,24-difluoro-1α,25-dihydroxyvitamin D3 from readily available vitamin D2
Ando,Koike,Takayama
, p. 189 - 192 (1995)
An improved synthesis of a highly potent vitamin D3 analog, 24,24-difluoro-1α,25-dihydroxyvitamin D3 (1b) has been accomplished via vitamin D2-SO2 adducts. The introduction of fluorine atoms was performed by tre
Synthesis of 24(28)-methylene-1α-hydroxyvitamin D3, a novel vitamin D3 analogue
Guo, Wei,Fang, Zhijie,Li, Hongliang,Liu, Yanan
, p. 231 - 235 (2014/05/06)
24(28)-Methylene-1α-hydroxyvitamin D3 was synthesised in 13 steps from vitamin D2. The key step of the synthesis involved the Wittig-Horner olefination of a nor-vitamin D2 aldehyde with diethylphosphono-3-methyl-2-butanone
An improved synthesis of 24,24-difluoro-1α,25-dihydroxy-vitamin D3 from vitamin D2
Ando,Kondo,Koike,Takayama
, p. 1662 - 1664 (2007/10/02)
An improved synthesis of a highly potent vitamin D3 analog, 24,24-difluoro-1α,25-dihydroxyvitamin D3 has been accomplished. The total yield was 9.3% from inexpensive vitamin D2 in 11 steps.