1345692-80-9

Basic information

• Product Name: 1-(2-fluorophenyl)-2-iodoethan-1-one
• Synonyms: 1-(2-fluorophenyl)-2-iodoethan-1-one
• CAS NO: 1345692-80-9
• Molecular Weight: 264.038
• Mol File: 1345692-80-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-(2-fluorophenyl)-2-iodoethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-fluorophenyl)-2-iodoethan-1-one(1345692-80-9)
• EPA Substance Registry System: 1-(2-fluorophenyl)-2-iodoethan-1-one(1345692-80-9)

Safety Data

• Hazardous Substances Data: 1345692-80-9(Hazardous Substances Data)

Upstream product

• 394-46-7 2-fluorostyrene 
• 1224178-39-5 1-fluoro-2-(iodoethynyl)benzene 
• 766-49-4 (2-fluorophenyl)acetylene 
• 445-27-2 2'-Fluoroacetophenone 

Relevant articles and documents

Metal-free hydration of aromatic haloalkynes to α-halomethyl ketones

A highly regioselective and efficient metal-free hydration of aromatic haloalkynes to α-halomethyl ketones using cheap tetrafluoroboric acid as catalyst is described. The protocol is conducted under convenient conditions and affords products in good to excellent yields, with broad substrate scope, including a variety of aromatic alkynyl chlorides, alkynyl bromides, and alkynyl iodides.

Au(I)-Catalyzed Hydration of 1-Iodoalkynes Leading to α-Iodoketones

A catalytic protocol for the Au(I)-catalyzed hydration of 1-iodoalkynes is disclosed. The use of Au(I)–NHC catalyst enabled the straightforward synthesis of a variety of α-iodomethyl ketones in good to excellent yields. The utility of this simple method is further highlighted by showcasing iodination/hydration and hydration/oxidation sequential protocols leading to the construction of molecular complexity.