766-49-4

Basic information

• Product Name: 1-ETHYNYL-2-FLUOROBENZENE
• Synonyms: 1-Ethynyl-2-fluorobenzene,97%;Benzene, 1-ethynyl-2-fluoro-;2-Fluorophenylacetylene 97%;1-Ethynyl-2-fluorobenzene, 97% 1GR;1-Ethynyl-2-fluorobenzene, 97% 250MG;2'-FLUOROPHENYL ACETYLENE;2-FLUOROPHENYLACETYLENE;1-ETHYNYL-2-FLUOROBENZENE
• CAS NO: 766-49-4
• Molecular Formula: C₈H₅F
• Molecular Weight: 120.12
• Product Categories: Alkynyl;Halogenated Hydrocarbons;Organic Building Blocks;Alkynyl Fluorinated Building Blocks;Building Blocks;Chemical Synthesis;Fluorinated Building Blocks;Halogenated Hydrocarbons;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks;Acetylenes;Acetylenic Hydrocarbons having Benzene Ring
• Mol File: 766-49-4.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 150 °C
• Flash Point: 37 °C
• Appearance: Clear yellow to brownish/Liquid
• Density: 1.06 g/mL at 25 °C(lit.)
• Vapor Pressure: 5.15mmHg at 25°C
• Refractive Index: 1.524-1.527
• Storage Temp.: Refrigerator (+4°C)
• CAS DataBase Reference: 1-ETHYNYL-2-FLUOROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-ETHYNYL-2-FLUOROBENZENE(766-49-4)
• EPA Substance Registry System: 1-ETHYNYL-2-FLUOROBENZENE(766-49-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-10
• Safety Statements: 37/39-26-16-36
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 3
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 766-49-4(Hazardous Substances Data)

Usage

Chemical Properties

clear yellow to brownish liquid

Uses

Different sources of media describe the Uses of 766-49-4 differently. You can refer to the following data:
1. Employed in studies on the polymerization1 and cross-coupling2 of phenylacetylenes.
2. 1-Ethynyl-2-fluorobenzene has been employed in the cross-coupling of phenylacetylenes. It may be used in the preparation of 3-(2-deoxy-β-D-ribofuranosyl)-6-(2-fluorophenyl)-2,3-dihydrofuro-[2,3-d]pyrimidin-2-one and 4-(2-fluorophenylethynyl)-3-methyl-5-phenylisoxazole.

Application

1-Ethynyl-2-fluorobenzene has been employed in the cross-coupling of phenylacetylenes. It may be used in the preparation of 3-(2-deoxy-β-D-ribofuranosyl)-6-(2-fluorophenyl)-2,3-dihydrofuro-[2,3-d]pyrimidin-2-one and 4-(2-fluorophenylethynyl)-3-methyl-5-phenylisoxazole.1-Ethynyl-2-fluorobenzene, a fluorinated benzene derivative, is a terminal alkyne.

General Description

1-Ethynyl-2-fluorobenzene, a fluorinated benzene derivative, is a terminal alkyne.

InChI:InChI=1/C8H5F/c1-2-7-5-3-4-6-8(7)9/h1,3-6H

Upstream product

• 480439-33-6 ((2-fluorophenyl)ethynyl)trimethylsilane 
• 401514-42-9 1-(2,2-dibromovinyl)-2-fluorobenzene 
• 348-52-7 1-Fluoro-2-iodobenzene 
• 446-52-6 2-Fluorobenzaldehyde 
• 445-26-1 1-(2-fluorophenyl)ethanol 
• 394-46-7 2-fluorostyrene 
• 1072-85-1 o-fluorobromobenzene 
• 342-19-8 2,3-Dibromo-3-(2-fluorophenyl)propionic acid 
• 18944-77-9 2-fluorocinnamic acid 
• 187463-12-3 (Z)-1-[2-bromovinyl]-2-fluorobenzene 
• 178173-84-7 4-(2-fluoro-phenyl)-2-methyl-but-3-yn-2-ol 

Downstream Products

• 29778-27-6 (2-(2-fluorophenyl)ethynyl)benzene 
• 1018853-16-1 C₈H₄BCl₂F 
• 942189-67-5 1-chloro-2-(2-fluoro-phenylethynyl)-4-nitro-benzene 

Relevant articles and documents

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Visible-Light-Promoted Vinylation of Tetrahydrofuran with Alkynes through Direct C-H Bond Functionalization

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