1346674-69-8

Basic information

• Product Name: (2,6-dibroMo-4-fluorophenyl)Methanol
• Synonyms: (2,6-dibroMo-4-fluorophenyl)Methanol
• CAS NO: 1346674-69-8
• Molecular Formula: C₇H₅Br₂FO
• Molecular Weight: 283.9204032
• EINECS: -0
• Mol File: 1346674-69-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 311.9±37.0 °C(Predicted)
• Appearance: /
• Density: 2.030±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.46±0.10(Predicted)
• CAS DataBase Reference: (2,6-dibroMo-4-fluorophenyl)Methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2,6-dibroMo-4-fluorophenyl)Methanol(1346674-69-8)
• EPA Substance Registry System: (2,6-dibroMo-4-fluorophenyl)Methanol(1346674-69-8)

Safety Data

• Hazardous Substances Data: 1346674-69-8(Hazardous Substances Data)

Usage

General Description

(2,6-dibromo-4-fluorophenyl)Methanol is a chemical compound with the molecular formula C7H6Br2FO and a molecular weight of 280.93 g/mol. It is an organic compound that contains both bromine and fluorine atoms. (2,6-dibroMo-4-fluorophenyl)Methanol is commonly used as a building block in the synthesis of various pharmaceutical and agrochemical products. It is a white powder that is sparingly soluble in water but soluble in most organic solvents. It is important for its role as an intermediate in the production of a variety of different chemicals and is typically handled and stored under standard laboratory conditions.

Upstream product

• 62720-29-0 1,3-dibromo-5-fluoro-2-iodobenzene 
• 938467-02-8 2,6-dibromo-4-fluorobenzaldehyde 

Downstream Products

• 1346675-25-9 2-(7,7-dimethyl-1-oxo-3,4,7,8-tetrahydro-1H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-2(6H)-yl)-4-fluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acetate 
• 1433989-85-5 (R)-2-(5-(5-(3,4-Dimethylpiperazin-1-yl)pyridin-2-ylamino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-4-fluoro-6-(1-oxo-3,4,6,7,8,9-hexahydropyrazino[1,2-a]indol-2(1H)-yl)benzyl acetate 
• 1433989-93-5 (R)-2-(5-((5-(2,4-dimethylpiperazin-1-yl)pyridin-2-yl)amino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-4-fluoro-6-(1-oxo-3,4,6,7,8,9-hexahydropyrazino[1,2-a]indol-2(1H)-yl)benzyl acetate 
• 1346676-93-4 4-fluoro-2-(5-(5-(3-(fluoromethyl)-4-methylpiperazin-1-yl)pyridin-2-ylamino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-6-(1-oxo-3,4,6,7,8,9-hexa-hydropyrazino[1,2-a]indol-2(1H)-yl)benzyl acetate 
• 1346671-86-0 2-(5-fluoro-3-(5-(5-(3-(fluoromethyl)-4-methylpiperazin-1-yl)pyridin-2-ylamino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-(hydroxymethyl)phenyl)-3,4,6,7,8,9-hexahydropyrazino[1,2-a]indol-1(2H)-one 
• 1433990-15-8 2-bromo-6-(7,7-difluoro-1-oxo-3,4,6,7,8,9-hexahydropyrazino[1,2-a]indol-2(1H)-yl)-4-fluorobenzyl Acetate 
• 1346677-00-6 (2-bromo-4-fluoro-6-{6-oxo-8-thia-4,5-diazatricyclo[7.4.0.0^2,7]trideca-1⁽⁹⁾,2⁽⁷⁾,3-trien-5-yl}phenyl)methyl acetate 
• 1433990-25-0 2-bromo-4-fluoro-6-(10-fluoro-1-oxo-3,4,6,7,8,9-hexahydropyrazino[1,2-a]indol-2(1H)-yl)benzyl acetate 
• 1433824-25-9 2-bromo-4-fluoro-6-(1-oxo-3,4,6,7,8,9-hexahydropyrido[3,4-b]-indolizin-2(1H)-yl)benzyl acetate 
• 1346674-61-0 2-bromo-4-fluoro-6-(9-oxo-4,4-dimethyl-1,10diazatricyclo[6.4.0.0^2,6]dodeca-2⁽⁶⁾,7-dien-10-yl)benzyl acetate 
• 1346674-62-1 2,6-dibromo-4-fluorobenzyl acetate 
• 1433824-03-3 4-fluoro-2-(6-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenylamino)-9H-purin-2-yl)-6-(1-oxo-3,4,6,7,8,9-hexahydropyrazino[1,2-a]indol-2(1H)-yl)benzyl acetate 
• 1433820-47-3 2-[5-fluoro-2-(hydroxymethyl)-3-[6-[4-[4-(oxetan-3-yl)piperazin-1-yl]anilino]-9H-purin-2-yl]phenyl]-3,4,6,7,8,9-hexahydropyrazino[1,2-a]indol-1-one 
• 1433820-64-4 2-[5-fluoro-2-(hydroxymethyl)-3-[6-[4-[4-(oxetan-3-yl)piperazin-1-yl]anilino]-9H-purin-2-yl]phenyl]-3,4,6,7,8,9-hexahydropyrido[3,4-b]indolizin-1-one 

Relevant articles and documents

Discovery of Potent and Selective Tricyclic Inhibitors of Bruton's Tyrosine Kinase with Improved Druglike Properties

In our continued effort to discover and develop best-in-class Bruton's tyrosine kinase (Btk) inhibitors for the treatment of B-cell lymphomas, rheumatoid arthritis, and systemic lupus erythematosus, we devised a series of novel tricyclic compounds that improved upon the druglike properties of our previous chemical matter. Compounds exemplified by G-744 are highly potent, selective for Btk, metabolically stable, well tolerated, and efficacious in an animal model of arthritis.

ALKYLATED PIPERAZINE COMPOUNDS

Alkylated piperazine compounds of Formula I are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.