135132-34-2Relevant articles and documents
Synthesis of difluoroaryldioxoles using BrF3
Hagooly, Youlia,Welch, Michael J.,Rozen, Shlomo
, p. 902 - 905 (2011)
A novel synthesis of different aromatic and heteroaromatic difluorodioxole derivatives has been developed. The starting materials were catechols, which, after treatment with thiophosgene, formed at 0 °C the respective thiodioxoles. The latter were reacted for a short time with commercially available bromine trifluoride, producing potentially biologically important difluoroaryldioxoles in moderate to high yields.
A 2, 2 - difluoro pepper acid methyl ester preparation method
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Paragraph 0027; 0030; 0031; 0035, (2017/09/26)
The invention discloses a preparation method of methyl 2,2-difluorobenzo[d][1,3]dioxole-5-carboxylate. The method comprises the steps of performing cyanation reaction to 5-bromo-2,2-difluoro-1,3-benzodioxole and cuprous cyanide, then performing hydrolysis to form acid, and then performing esterification to obtain 2,2-difluorobenzo[d][1,3]dioxole-5-carboxylate. In the preparation method disclosed by the invention, by using 5-bromo-2,2-difluoro-1,3-benzodioxole as a start raw material, performing cyanation by using low-toxicity cuprous cyanide, then performing hydrolysis to form acid and performing methanol reaction esterification to obtain the product, the process flow of the method is simple and the reaction process is easy to control. In the reaction process, the purification of the intermediate product produced in each step does not need a complex purification process, the purification process is simple, the purification yield is high, the entire process flow is simple and high-efficiency, the product yield is high, the cost of the entire flow is low and the preparation method is very suitable for large-scale industrial production.
