1352131-41-9

Basic information

• Product Name: 5-hydroxy-5-(2,4,6-trimethylphenyl)-N,N'-diphenylimidazolidine-2,4-dione
• CAS NO: 1352131-41-9
• Molecular Weight: 386.45
• Mol File: 1352131-41-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-hydroxy-5-(2,4,6-trimethylphenyl)-N,N'-diphenylimidazolidine-2,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-hydroxy-5-(2,4,6-trimethylphenyl)-N,N'-diphenylimidazolidine-2,4-dione(1352131-41-9)
• EPA Substance Registry System: 5-hydroxy-5-(2,4,6-trimethylphenyl)-N,N'-diphenylimidazolidine-2,4-dione(1352131-41-9)

Safety Data

• Hazardous Substances Data: 1352131-41-9(Hazardous Substances Data)

Upstream product

• 576-83-0 2,4,6-trimethylphenyl bromide 
• 6488-59-1 diphenylparabanic acid 
• 102-07-8 bis(diphenyl)urea 

Downstream Products

• 1267021-88-4 2-oxo-N-phenyl-2-(2,4,6-trimethylphenyl)acetamide 
• 3112-46-7 mesitylglyoxylic acid 

Relevant articles and documents

Diphenylparabanic acid as a synthon for the synthesis of α-diketones and α-ketocarboxylic acids

Diphenylparabanic acid was found to react with >2 equiv of organolithiums at -78 °C to effectively give the corresponding symmetrical α-diketones. However, upon treatment with 1 equiv of organolithium, the parabanic acid gave mainly 5-substituted 5-hydroxyimidazolidine-2,4-diones. On the other hand, Grignard reagents were less reactive toward the parabanic acid at low temperature, and selectively gave the corresponding 5- hydroxyimidazolidine-2,4-diones even if more than 1 equiv of the reagents was used. A tandem process in which the parabanic acid was first reacted with a Grignard reagent and then reacted in one-pot with an organolithium effectively gave the unsymmetrical α-diketone. 5-Substituted 5-hydroxyimidazolidine-2, 4-diones were useful as versatile precursors for preparing α- ketocarboxylic acids as well as unsymmetrical α-diketones.