6488-59-1Relevant articles and documents
Urea Cyclisation Reaction Studies
Niddam, Valerie,Medou, Martial,Dessolin, Jean,Trabaud, Carole,Camplo, Michel,Kraus, Jean-Louis
, p. 829 - 833 (1997)
Synthetic approaches of N-α-hydroxyalkyl amides or urea derivatives are described. In particularly, a new 1,4,6-oxadiazocine-2,5,8-trione was obtained by condensation of glyoxylic acid on urea derivatives in acidic catalysis condition.
Diphenylparabanic acid as a synthon for the synthesis of α-diketones and α-ketocarboxylic acids
Watanabe, Nobuko,Hamano, Mitsutaka,Todaka, Shota,Asaeda, Takahiro,Ijuin, Hisako K.,Matsumoto, Masakatsu
experimental part, p. 632 - 639 (2012/03/22)
Diphenylparabanic acid was found to react with >2 equiv of organolithiums at -78 °C to effectively give the corresponding symmetrical α-diketones. However, upon treatment with 1 equiv of organolithium, the parabanic acid gave mainly 5-substituted 5-hydroxyimidazolidine-2,4-diones. On the other hand, Grignard reagents were less reactive toward the parabanic acid at low temperature, and selectively gave the corresponding 5- hydroxyimidazolidine-2,4-diones even if more than 1 equiv of the reagents was used. A tandem process in which the parabanic acid was first reacted with a Grignard reagent and then reacted in one-pot with an organolithium effectively gave the unsymmetrical α-diketone. 5-Substituted 5-hydroxyimidazolidine-2, 4-diones were useful as versatile precursors for preparing α- ketocarboxylic acids as well as unsymmetrical α-diketones.
Dibutyltin oxide catalyzed aminolysis of oxalate to carbamate, oxamate and derivatives of imidazolidine trione
Kunde, Lalita B.,Kalyani, Vishwanath S.,Gupte, Sunil P.
experimental part, p. 402 - 407 (2010/08/06)
Catalytic aminolysis of oxalates by simple and substituted ureas has been shown to give carbamates, oxamates and derivatives of imidazolidine trione. Various substituted ureas and oxalates were screened to verify the applicability of the protocol. The rol
