1353548-60-3

Basic information

• Product Name: C₃₃H₄₅NO₉
• Synonyms: C₃₃H₄₅NO₉
• CAS NO: 1353548-60-3
• Molecular Weight: 599.722
• Mol File: 1353548-60-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₃₃H₄₅NO₉(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₃H₄₅NO₉(1353548-60-3)
• EPA Substance Registry System: C₃₃H₄₅NO₉(1353548-60-3)

Safety Data

• Hazardous Substances Data: 1353548-60-3(Hazardous Substances Data)

Upstream product

• 1353548-62-5 C₂₉H₃₆O₉ 
• 1353548-63-6 C₃₃H₄₃NO₉ 
• 184586-82-1 C₃₂H₄₀O₉ 
• 173422-30-5 (1S,2S,3R,4S,5R,7S,8R,10R,13S)-4-acetoxy-2-benzoyloxy-5,20-epoxy-9-oxo-1,10,13-trihydroxytax-11-ene 
• 272129-02-9 (1S,2S,3R,4S,5R,7S,8R,10R,13S)-4-acetoxy-2-benzoyloxy-5,20-epoxy-9-oxo-1,10,13-trihydroxytax-6,11-diene 
• 170575-25-4 7-OTf-10DAB 
• 184586-81-0 (1S,2S,3R,4S,5R,8R,9S,10R,13S)-4-(acetoxy)-2-(benzoyloxy)-5,20-epoxy-1,9,10,13-tetrahydroxytax-11-ene 
• 162475-68-5 10-deacetyl-9β-dihydrobaccatin III 
• 32981-86-5 10-deacetylbaccatin III 
• 506-59-2 N,N-dimethylammonium chloride 

Downstream Products

• 333754-43-1 (1S,2S,3R,4S,5R,8R,9S,10R,13S)-4-acetoxy-2-benzoyloxy-9,10-[(1S)-2-(dimethylamino)ethylidenedioxy]-5,20-epoxy-1-hydroxytax-11-en-13-yl (2R,3S)-3-(tert-butoxycarbonylamino)-3-(3-fluoro-2-pyridyl)-2-triisopropylsilyloxypropionate 

Relevant articles and documents

Degradation pathway of a taxane derivative DS80100717 drug substance and drug product

The degradation pathway of a taxane derivative and anticancer agent, DS80100717, was investigated. Several degradants were generated under acidic, basic, and oxidative stress conditions in solution. The chemical structures of eight degradants of DS80100717 were elucidated using MS and NMR. The major degradant of the DS80100717 drug substance derived by heating in solid-state was the N-oxide form via oxidation and C2′-epimer of the side chain via acid hydrolysis. We proposed previously unreported degradation pathways of DS80100717 with taxane derivatives such as paclitaxel, docetaxel, and cabazitaxel.